TargetNet
  Target name

P00735: Prothrombin

  Protein function

Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity).

  Database links
Uniprot primary ID P00735
PDB ID 1YCP 3PMB 1BBR 3PMA 1TOC 2HPP 2SPT 1ETT 1ETR 1ETS 1ID5 1UVT 1UVU 1MKW 2A1D 1MKX 2ODY 2PF1 2PF2 1VIT 1TBQ 1TBR 1HRT 1A0H 1AVG 1NL1 1NL2 1UCY
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID
PharmGKB ID
KEGG ID bta:280685
DIP ID DIP-6099N
STRING ID 9913.ENSBTAP00000009406
IntAct ID P00735
DMDM
BRENDA 3.4.21.5
Reactome R-BTA-416476 R-BTA-140875 R-BTA-456926 R-BTA-381426 R-BTA-140837 R-BTA-202733 R-BTA-159740 R-BTA-159782 R-BTA-159763 R-BTA-375276 R-BTA-76009
SignaLink
BioCyc
Entrez Gene (Gene ID) 280685
BindingDB P00735
  Model Performance Metrics
Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.810 0.000 0.950 0.005 0.880 0.000 0.871 0.003 0.885 0.005 0.770 0.005 Download
Estate fingerprints 0.823 0.005 0.913 0.005 0.868 0.004 0.860 0.000 0.926 0.005 0.735 0.005 Download
MACCS fingerprints 0.820 0.000 0.900 0.004 0.860 0.000 0.852 0.004 0.879 0.003 0.722 0.004 Download
Daylight fingerprints 0.730 0.000 0.972 0.007 0.851 0.003 0.831 0.003 0.893 0.005 0.728 0.006 Download
ECFP2 fingerprints 0.820 0.000 0.960 0.004 0.890 0.000 0.880 0.000 0.940 0.000 0.788 0.004 Download
ECFP4 fingerprints 0.820 0.000 0.980 0.003 0.900 0.000 0.890 0.000 0.950 0.000 0.811 0.003 Download
ECFP6 fingerprints 0.811 0.003 0.989 0.000 0.900 0.000 0.890 0.000 0.942 0.004 0.811 0.003 Download
  Download datasets
Positive dataset Negative dataset

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 E-mail: biomed@csu.edu.cn