Target name

P00742: Coagulation factor X


  Protein function

Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.

  Database links

Uniprot primary ID P00742
PDB ID 1IOE 3CEN 2J34 1C5M 2PHB 2J38 2XC5 2XC4 2XC0 2Y7Z 2JKH 2Y7X 2BQW 2GD4 3ENS 2FZZ 2Q1J 2XBX 2XBY 1V3X 2XBV 2XBW 1IQI 2J4I 2P95 2P94 3KQC 3KQB 3KQE 3KQD 2P93 2PR3 2WYJ 2Y82 2Y81 2Y80 2WYG 1MQ5 1IQH 1IQK 1MQ6 1LQD 1KSN 2VVV 1FAX 1FXY 3FFG 2BQ7 2BQ6 3IIT 1P0S
DrugBank ID DB01109 DB00100 DB09075 DB06228 DB06605 DB01225 DB00025
BioGrid ID 108457
GuidetoPHARMACOLOGY ID 2359
PharmGKB ID PA27940
KEGG ID hsa:2159
DIP ID DIP-29896N
STRING ID 9606.ENSP00000364709
IntAct ID P00742
DMDM 119761
BRENDA 3.4.21.6
Reactome R-HSA-159740 R-HSA-140834 R-HSA-159782 R-HSA-140837 R-HSA-140875 R-HSA-159763
SignaLink
BioCyc MetaCyc:HS05000-MONOMER
Entrez Gene (Gene ID) 2159
BindingDB P00742

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.800 0.000 0.860 0.000 0.830 0.000 0.830 0.000 0.920 0.000 0.670 0.000 Download
Estate fingerprints 0.870 0.000 0.830 0.000 0.850 0.000 0.850 0.000 0.920 0.000 0.700 0.000 Download
MACCS fingerprints 0.746 0.005 0.814 0.000 0.780 0.000 0.770 0.000 0.860 0.000 0.560 0.000 Download
Daylight fingerprints 0.790 0.000 0.710 0.005 0.750 0.000 0.760 0.000 0.810 0.000 0.498 0.004 Download
ECFP2 fingerprints 0.960 0.000 0.932 0.000 0.946 0.005 0.950 0.000 0.980 0.000 0.890 0.000 Download
ECFP4 fingerprints 0.960 0.000 0.980 0.000 0.970 0.000 0.970 0.000 0.990 0.000 0.930 0.000 Download
ECFP6 fingerprints 0.930 0.000 0.984 0.000 0.957 0.005 0.950 0.000 0.990 0.000 0.910 0.000 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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