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Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells.
| Uniprot primary ID | P00747 |
| PDB ID | 4DUR 1KRN 4DUU 1RJX 1QRZ 2DOI 2DOH 1PK4 2PK4 1BUI 1PMK 2KNF 1HPK 1DDJ 1B2I 1HPJ 1PKR 3UIR 1CEB 1CEA 1L4Z 4DCB 2L0S 1BML 4CIK 4A5T 1KI0 1L4D 5HPG 1I5K |
| DrugBank ID | DB00513 DB00086 DB00031 DB00009 DB00013 DB00302 DB00029 |
| BioGrid ID | 111356 |
| GuidetoPHARMACOLOGY ID | 2394 |
| PharmGKB ID | PA33405 |
| KEGG ID | hsa:5340 |
| DIP ID | |
| STRING ID | 9606.ENSP00000308938 |
| IntAct ID | P00747 |
| DMDM | 130316 |
| BRENDA | 3.4.21.7 |
| Reactome | R-HSA-381426 R-HSA-75205 R-HSA-114608 R-HSA-1474228 R-HSA-1592389 R-HSA-186797 |
| SignaLink | |
| BioCyc | MetaCyc:HS04553-MONOMER |
| Entrez Gene (Gene ID) | 5340 |
| BindingDB | P00747 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.687 | 0.005 | 0.895 | 0.005 | 0.791 | 0.006 | 0.767 | 0.005 | 0.916 | 0.005 | 0.595 | 0.008 | Download |
| Estate fingerprints | 0.877 | 0.005 | 0.911 | 0.000 | 0.894 | 0.005 | 0.892 | 0.004 | 0.960 | 0.000 | 0.792 | 0.004 | Download |
| MACCS fingerprints | 0.731 | 0.003 | 0.869 | 0.003 | 0.800 | 0.000 | 0.782 | 0.004 | 0.920 | 0.000 | 0.601 | 0.003 | Download |
| Daylight fingerprints | 0.683 | 0.005 | 0.925 | 0.003 | 0.804 | 0.005 | 0.779 | 0.003 | 0.910 | 0.000 | 0.631 | 0.006 | Download |
| ECFP2 fingerprints | 0.920 | 0.000 | 0.940 | 0.005 | 0.930 | 0.000 | 0.930 | 0.000 | 0.980 | 0.000 | 0.859 | 0.003 | Download |
| ECFP4 fingerprints | 0.933 | 0.005 | 0.965 | 0.000 | 0.949 | 0.003 | 0.948 | 0.004 | 0.980 | 0.000 | 0.896 | 0.005 | Download |
| ECFP6 fingerprints | 0.910 | 0.000 | 0.970 | 0.005 | 0.940 | 0.000 | 0.939 | 0.003 | 0.980 | 0.000 | 0.880 | 0.005 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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