Target name

P00747: Plasminogen


  Protein function

Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells.

  Database links

Uniprot primary ID P00747
PDB ID 4DUR 1KRN 4DUU 1RJX 1QRZ 2DOI 2DOH 1PK4 2PK4 1BUI 1PMK 2KNF 1HPK 1DDJ 1B2I 1HPJ 1PKR 3UIR 1CEB 1CEA 1L4Z 4DCB 2L0S 1BML 4CIK 4A5T 1KI0 1L4D 5HPG 1I5K
DrugBank ID DB00513 DB00086 DB00031 DB00009 DB00013 DB00302 DB00029
BioGrid ID 111356
GuidetoPHARMACOLOGY ID 2394
PharmGKB ID PA33405
KEGG ID hsa:5340
DIP ID
STRING ID 9606.ENSP00000308938
IntAct ID P00747
DMDM 130316
BRENDA 3.4.21.7
Reactome R-HSA-381426 R-HSA-75205 R-HSA-114608 R-HSA-1474228 R-HSA-1592389 R-HSA-186797
SignaLink
BioCyc MetaCyc:HS04553-MONOMER
Entrez Gene (Gene ID) 5340
BindingDB P00747

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.687 0.005 0.895 0.005 0.791 0.006 0.767 0.005 0.916 0.005 0.595 0.008 Download
Estate fingerprints 0.877 0.005 0.911 0.000 0.894 0.005 0.892 0.004 0.960 0.000 0.792 0.004 Download
MACCS fingerprints 0.731 0.003 0.869 0.003 0.800 0.000 0.782 0.004 0.920 0.000 0.601 0.003 Download
Daylight fingerprints 0.683 0.005 0.925 0.003 0.804 0.005 0.779 0.003 0.910 0.000 0.631 0.006 Download
ECFP2 fingerprints 0.920 0.000 0.940 0.005 0.930 0.000 0.930 0.000 0.980 0.000 0.859 0.003 Download
ECFP4 fingerprints 0.933 0.005 0.965 0.000 0.949 0.003 0.948 0.004 0.980 0.000 0.896 0.005 Download
ECFP6 fingerprints 0.910 0.000 0.970 0.005 0.940 0.000 0.939 0.003 0.980 0.000 0.880 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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