Details-Calcnet-TargetNet

Target name

P00750: Tissue-type plasminogen activator

Protein function

Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. Plays a direct role in facilitating neuronal migration.

Database links

Uniprot primary ID	P00750
PDB ID	1BDA 1TPK 1PML 1A5H 1TPM 1RTF 1TPG 1PK2 5BRR 1TPN
DrugBank ID	DB00513 DB01050 DB01088 DB00013
BioGrid ID	111343
GuidetoPHARMACOLOGY ID	2392
PharmGKB ID	PA33381
KEGG ID	hsa:5327
DIP ID
STRING ID	9606.ENSP00000220809
IntAct ID	P00750
DMDM	137119
BRENDA	3.4.21.68
Reactome	R-HSA-186797 R-HSA-75205
SignaLink
BioCyc
Entrez Gene (Gene ID)	5327
BindingDB	P00750

Model Performance Metrics

Fingerprint type	Sensitivity	SEN_std	Specificity	SPE_std	Accuracy	ACC_std	F1-score	F1-score_std	AUC	AUC_std	MCC	MCC_std	Download model
FP2 fingerprints	0.827	0.016	0.883	0.009	0.855	0.010	0.852	0.011	0.936	0.005	0.714	0.018	Download
Estate fingerprints	0.745	0.005	0.873	0.005	0.809	0.003	0.797	0.005	0.880	0.000	0.623	0.007	Download
MACCS fingerprints	0.773	0.008	0.865	0.005	0.819	0.003	0.809	0.003	0.914	0.005	0.637	0.007	Download
Daylight fingerprints	0.818	0.006	0.760	0.008	0.789	0.007	0.796	0.005	0.878	0.004	0.580	0.012	Download
ECFP2 fingerprints	0.926	0.008	0.916	0.013	0.921	0.007	0.921	0.007	0.970	0.000	0.841	0.017	Download
ECFP4 fingerprints	0.957	0.007	0.957	0.007	0.957	0.005	0.956	0.005	0.981	0.003	0.910	0.005	Download
ECFP6 fingerprints	0.897	0.008	0.959	0.008	0.928	0.004	0.924	0.005	0.980	0.000	0.855	0.008	Download

Download datasets

Positive dataset

Negative dataset