Target name

P00750: Tissue-type plasminogen activator


  Protein function

Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. Plays a direct role in facilitating neuronal migration.

  Database links

Uniprot primary ID P00750
PDB ID 1BDA 1TPK 1PML 1A5H 1TPM 1RTF 1TPG 1PK2 5BRR 1TPN
DrugBank ID DB00513 DB01050 DB01088 DB00013
BioGrid ID 111343
GuidetoPHARMACOLOGY ID 2392
PharmGKB ID PA33381
KEGG ID hsa:5327
DIP ID
STRING ID 9606.ENSP00000220809
IntAct ID P00750
DMDM 137119
BRENDA 3.4.21.68
Reactome R-HSA-186797 R-HSA-75205
SignaLink
BioCyc
Entrez Gene (Gene ID) 5327
BindingDB P00750

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.827 0.016 0.883 0.009 0.855 0.010 0.852 0.011 0.936 0.005 0.714 0.018 Download
Estate fingerprints 0.745 0.005 0.873 0.005 0.809 0.003 0.797 0.005 0.880 0.000 0.623 0.007 Download
MACCS fingerprints 0.773 0.008 0.865 0.005 0.819 0.003 0.809 0.003 0.914 0.005 0.637 0.007 Download
Daylight fingerprints 0.818 0.006 0.760 0.008 0.789 0.007 0.796 0.005 0.878 0.004 0.580 0.012 Download
ECFP2 fingerprints 0.926 0.008 0.916 0.013 0.921 0.007 0.921 0.007 0.970 0.000 0.841 0.017 Download
ECFP4 fingerprints 0.957 0.007 0.957 0.007 0.957 0.005 0.956 0.005 0.981 0.003 0.910 0.005 Download
ECFP6 fingerprints 0.897 0.008 0.959 0.008 0.928 0.004 0.924 0.005 0.980 0.000 0.855 0.008 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
 E-mail: biomed@csu.edu.cn