Target name

P00915: Carbonic anhydrase 1


  Protein function

Reversible hydration of carbon dioxide. Can hydrates cyanamide to urea.

  Database links

Uniprot primary ID P00915
PDB ID 1HUH 2FW4 4WUP 4WUQ 1AZM 1HUG 3W6H 3W6I 2FOY 4WR7 1HCB 2CAB 1J9W 2NMX 2NN7 1JV0 2NN1 2IT4 1CRM 1BZM 3LXE 1CZM
DrugBank ID DB01119 DB01144 DB01194 DB01021 DB01031 DB00880 DB00909
BioGrid ID 107214
GuidetoPHARMACOLOGY ID 2597
PharmGKB ID PA25984
KEGG ID hsa:759
DIP ID
STRING ID 9606.ENSP00000256119
IntAct ID P00915
DMDM 115449
BRENDA 4.2.1.1
Reactome R-HSA-1247673 R-HSA-1237044 R-HSA-1475029
SignaLink
BioCyc
Entrez Gene (Gene ID) 759
BindingDB P00915

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.916 0.005 0.904 0.000 0.910 0.000 0.910 0.000 0.960 0.000 0.830 0.000 Download
Estate fingerprints 0.900 0.000 0.920 0.000 0.910 0.000 0.910 0.000 0.960 0.000 0.820 0.000 Download
MACCS fingerprints 0.890 0.000 0.870 0.000 0.880 0.000 0.880 0.000 0.960 0.000 0.760 0.000 Download
Daylight fingerprints 0.700 0.000 0.820 0.005 0.760 0.000 0.750 0.000 0.810 0.000 0.530 0.000 Download
ECFP2 fingerprints 0.931 0.003 0.969 0.000 0.950 0.000 0.950 0.000 0.990 0.000 0.899 0.003 Download
ECFP4 fingerprints 0.929 0.003 0.971 0.000 0.950 0.000 0.950 0.000 0.990 0.000 0.899 0.003 Download
ECFP6 fingerprints 0.930 0.000 0.970 0.000 0.950 0.000 0.950 0.000 0.990 0.000 0.909 0.003 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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