Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Key mediator of cell death in the anticancer action of BCG-stimulated neutrophils in combination with DIABLO/SMAC mimetic in the RT4v6 bladder cancer cell line (PubMed:22517918).
| Uniprot primary ID | P01375 |
| PDB ID | 2ZPX 1A8M 5TSW 4TSV 2AZ5 2ZJC 2E7A 3IT8 2TUN 1TNF 3ALQ 3WD5 3L9J 4TWT 4G3Y |
| DrugBank ID | DB00608 DB01411 DB00668 DB00065 DB01427 DB00852 DB08910 |
| BioGrid ID | 112979 |
| GuidetoPHARMACOLOGY ID | 2635 |
| PharmGKB ID | PA435 |
| KEGG ID | hsa:7124 |
| DIP ID | DIP-2895N |
| STRING ID | 9606.ENSP00000398698 |
| IntAct ID | P01375 |
| DMDM | 135934 |
| BRENDA | |
| Reactome | R-HSA-75893 R-HSA-5357786 R-HSA-381340 R-HSA-5668541 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 7124 |
| BindingDB | P01375 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.410 | 0.000 | 0.970 | 0.000 | 0.690 | 0.000 | 0.570 | 0.000 | 0.800 | 0.000 | 0.461 | 0.003 | Download |
| Estate fingerprints | 0.641 | 0.003 | 0.755 | 0.005 | 0.698 | 0.004 | 0.678 | 0.004 | 0.780 | 0.000 | 0.401 | 0.007 | Download |
| MACCS fingerprints | 0.618 | 0.004 | 0.776 | 0.005 | 0.697 | 0.005 | 0.670 | 0.000 | 0.750 | 0.000 | 0.399 | 0.007 | Download |
| Daylight fingerprints | 0.410 | 0.000 | 0.980 | 0.000 | 0.695 | 0.005 | 0.574 | 0.005 | 0.710 | 0.000 | 0.474 | 0.005 | Download |
| ECFP2 fingerprints | 0.584 | 0.005 | 0.934 | 0.005 | 0.759 | 0.003 | 0.709 | 0.003 | 0.880 | 0.000 | 0.552 | 0.006 | Download |
| ECFP4 fingerprints | 0.509 | 0.006 | 0.977 | 0.005 | 0.743 | 0.005 | 0.663 | 0.005 | 0.898 | 0.004 | 0.549 | 0.007 | Download |
| ECFP6 fingerprints | 0.449 | 0.003 | 0.991 | 0.000 | 0.720 | 0.000 | 0.617 | 0.005 | 0.889 | 0.003 | 0.529 | 0.003 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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