Target name

P01375: Tumor necrosis factor


  Protein function

Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Key mediator of cell death in the anticancer action of BCG-stimulated neutrophils in combination with DIABLO/SMAC mimetic in the RT4v6 bladder cancer cell line (PubMed:22517918).

  Database links

Uniprot primary ID P01375
PDB ID 2ZPX 1A8M 5TSW 4TSV 2AZ5 2ZJC 2E7A 3IT8 2TUN 1TNF 3ALQ 3WD5 3L9J 4TWT 4G3Y
DrugBank ID DB00608 DB01411 DB00668 DB00065 DB01427 DB00852 DB08910
BioGrid ID 112979
GuidetoPHARMACOLOGY ID 2635
PharmGKB ID PA435
KEGG ID hsa:7124
DIP ID DIP-2895N
STRING ID 9606.ENSP00000398698
IntAct ID P01375
DMDM 135934
BRENDA
Reactome R-HSA-75893 R-HSA-5357786 R-HSA-381340 R-HSA-5668541
SignaLink
BioCyc
Entrez Gene (Gene ID) 7124
BindingDB P01375

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.410 0.000 0.970 0.000 0.690 0.000 0.570 0.000 0.800 0.000 0.461 0.003 Download
Estate fingerprints 0.641 0.003 0.755 0.005 0.698 0.004 0.678 0.004 0.780 0.000 0.401 0.007 Download
MACCS fingerprints 0.618 0.004 0.776 0.005 0.697 0.005 0.670 0.000 0.750 0.000 0.399 0.007 Download
Daylight fingerprints 0.410 0.000 0.980 0.000 0.695 0.005 0.574 0.005 0.710 0.000 0.474 0.005 Download
ECFP2 fingerprints 0.584 0.005 0.934 0.005 0.759 0.003 0.709 0.003 0.880 0.000 0.552 0.006 Download
ECFP4 fingerprints 0.509 0.006 0.977 0.005 0.743 0.005 0.663 0.005 0.898 0.004 0.549 0.007 Download
ECFP6 fingerprints 0.449 0.003 0.991 0.000 0.720 0.000 0.617 0.005 0.889 0.003 0.529 0.003 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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