Target name

P03956: Interstitial collagenase


  Protein function

Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity.

  Database links

Uniprot primary ID P03956
PDB ID 1AYK 1CGE 4AYK 1CGF 1SU3 2CLT 2TCL 2J0T 1CGL 3SHI 1HFC 966C 2AYK 3AYK 4AUO
DrugBank ID DB00786
BioGrid ID 110456
GuidetoPHARMACOLOGY ID 1628
PharmGKB ID PA30867
KEGG ID
DIP ID DIP-529N
STRING ID 9606.ENSP00000322788
IntAct ID P03956
DMDM 116852
BRENDA 3.4.24.7
Reactome R-HSA-1592389 R-HSA-381426 R-HSA-1474228 R-HSA-210991 R-HSA-1442490
SignaLink
BioCyc
Entrez Gene (Gene ID) 4312
BindingDB P03956

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.870 0.000 0.890 0.004 0.880 0.000 0.880 0.000 0.950 0.000 0.760 0.000 Download
Estate fingerprints 0.890 0.000 0.830 0.004 0.860 0.000 0.860 0.000 0.940 0.000 0.719 0.003 Download
MACCS fingerprints 0.850 0.000 0.876 0.000 0.863 0.005 0.860 0.000 0.950 0.000 0.730 0.000 Download
Daylight fingerprints 0.800 0.000 0.900 0.000 0.850 0.000 0.840 0.000 0.920 0.000 0.701 0.003 Download
ECFP2 fingerprints 0.935 0.005 0.943 0.003 0.939 0.003 0.939 0.003 0.980 0.000 0.871 0.003 Download
ECFP4 fingerprints 0.950 0.000 0.968 0.003 0.959 0.003 0.957 0.005 0.990 0.000 0.910 0.000 Download
ECFP6 fingerprints 0.930 0.000 0.970 0.005 0.950 0.000 0.950 0.000 0.990 0.000 0.900 0.000 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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