Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.
| Uniprot primary ID | P04035 |
| PDB ID | 1HW8 1HWL 2Q6B 1HWJ 1HWK 1HWI 2Q1L 3CD0 3CD7 3CD5 3CCW 3CCT 1DQA 1DQ8 1DQ9 3BGL 3CCZ 3CDB 3CDA 2Q6C 1HW9 2R4F |
| DrugBank ID | DB01076 DB01098 DB00641 DB01095 DB00227 DB00175 DB08860 |
| BioGrid ID | 109399 |
| GuidetoPHARMACOLOGY ID | 639 |
| PharmGKB ID | PA189 |
| KEGG ID | hsa:3156 |
| DIP ID | |
| STRING ID | 9606.ENSP00000287936 |
| IntAct ID | P04035 |
| DMDM | 123343 |
| BRENDA | 1.1.1.34 |
| Reactome | R-HSA-1989781 R-HSA-191273 R-HSA-2426168 |
| SignaLink | |
| BioCyc | MetaCyc:HS03652-MONOMER |
| Entrez Gene (Gene ID) | 3156 |
| BindingDB | P04035 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.893 | 0.008 | 0.987 | 0.000 | 0.940 | 0.000 | 0.938 | 0.004 | 0.990 | 0.000 | 0.885 | 0.005 | Download |
| Estate fingerprints | 0.978 | 0.004 | 0.942 | 0.000 | 0.960 | 0.000 | 0.960 | 0.000 | 0.990 | 0.000 | 0.914 | 0.005 | Download |
| MACCS fingerprints | 0.960 | 0.000 | 0.980 | 0.000 | 0.970 | 0.000 | 0.970 | 0.000 | 0.999 | 0.003 | 0.940 | 0.000 | Download |
| Daylight fingerprints | 0.781 | 0.009 | 0.963 | 0.004 | 0.872 | 0.004 | 0.858 | 0.008 | 0.866 | 0.005 | 0.751 | 0.012 | Download |
| ECFP2 fingerprints | 0.943 | 0.009 | 1.000 | 0.000 | 0.972 | 0.008 | 0.969 | 0.006 | 1.000 | 0.000 | 0.944 | 0.010 | Download |
| ECFP4 fingerprints | 0.960 | 0.009 | 0.998 | 0.000 | 0.979 | 0.003 | 0.978 | 0.004 | 1.000 | 0.000 | 0.960 | 0.009 | Download |
| ECFP6 fingerprints | 0.937 | 0.008 | 1.000 | 0.000 | 0.971 | 0.006 | 0.969 | 0.003 | 1.000 | 0.000 | 0.938 | 0.009 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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