PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides, this releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules.
| Uniprot primary ID | P04054 |
| PDB ID | 1YSK 3ELO |
| DrugBank ID | DB00795 DB04552 DB02659 |
| BioGrid ID | 111336 |
| GuidetoPHARMACOLOGY ID | |
| PharmGKB ID | PA33361 |
| KEGG ID | hsa:5319 |
| DIP ID | |
| STRING ID | 9606.ENSP00000312286 |
| IntAct ID | P04054 |
| DMDM | 129404 |
| BRENDA | |
| Reactome | R-HSA-1483166 R-HSA-1482839 R-HSA-1482801 R-HSA-1482925 R-HSA-1482922 R-HSA-1482788 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 5319 |
| BindingDB | P04054 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.535 | 0.011 | 0.839 | 0.011 | 0.687 | 0.008 | 0.630 | 0.009 | 0.747 | 0.005 | 0.393 | 0.019 | Download |
| Estate fingerprints | 0.691 | 0.007 | 0.687 | 0.011 | 0.689 | 0.003 | 0.691 | 0.006 | 0.774 | 0.005 | 0.383 | 0.011 | Download |
| MACCS fingerprints | 0.709 | 0.007 | 0.745 | 0.008 | 0.727 | 0.007 | 0.720 | 0.007 | 0.782 | 0.004 | 0.453 | 0.009 | Download |
| Daylight fingerprints | 0.442 | 0.008 | 0.834 | 0.011 | 0.638 | 0.009 | 0.549 | 0.009 | 0.639 | 0.006 | 0.299 | 0.014 | Download |
| ECFP2 fingerprints | 0.731 | 0.013 | 0.809 | 0.007 | 0.770 | 0.007 | 0.762 | 0.008 | 0.871 | 0.003 | 0.542 | 0.013 | Download |
| ECFP4 fingerprints | 0.694 | 0.012 | 0.860 | 0.011 | 0.777 | 0.008 | 0.756 | 0.008 | 0.875 | 0.005 | 0.563 | 0.016 | Download |
| ECFP6 fingerprints | 0.635 | 0.016 | 0.887 | 0.011 | 0.761 | 0.009 | 0.725 | 0.012 | 0.857 | 0.005 | 0.540 | 0.020 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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