TargetNet
  Target name

P04054: Phospholipase A2

  Protein function

PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides, this releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules.

  Database links
Uniprot primary ID P04054
PDB ID 1YSK 3ELO
DrugBank ID DB00795 DB04552 DB02659
BioGrid ID 111336
GuidetoPHARMACOLOGY ID
PharmGKB ID PA33361
KEGG ID hsa:5319
DIP ID
STRING ID 9606.ENSP00000312286
IntAct ID P04054
DMDM 129404
BRENDA
Reactome R-HSA-1483166 R-HSA-1482839 R-HSA-1482801 R-HSA-1482925 R-HSA-1482922 R-HSA-1482788
SignaLink
BioCyc
Entrez Gene (Gene ID) 5319
BindingDB P04054
  Model Performance Metrics
Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.535 0.011 0.839 0.011 0.687 0.008 0.630 0.009 0.747 0.005 0.393 0.019 Download
Estate fingerprints 0.691 0.007 0.687 0.011 0.689 0.003 0.691 0.006 0.774 0.005 0.383 0.011 Download
MACCS fingerprints 0.709 0.007 0.745 0.008 0.727 0.007 0.720 0.007 0.782 0.004 0.453 0.009 Download
Daylight fingerprints 0.442 0.008 0.834 0.011 0.638 0.009 0.549 0.009 0.639 0.006 0.299 0.014 Download
ECFP2 fingerprints 0.731 0.013 0.809 0.007 0.770 0.007 0.762 0.008 0.871 0.003 0.542 0.013 Download
ECFP4 fingerprints 0.694 0.012 0.860 0.011 0.777 0.008 0.756 0.008 0.875 0.005 0.563 0.016 Download
ECFP6 fingerprints 0.635 0.016 0.887 0.011 0.761 0.009 0.725 0.012 0.857 0.005 0.540 0.020 Download
  Download datasets
Positive dataset Negative dataset

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 E-mail: biomed@csu.edu.cn