Target name

P04058: Acetylcholinesterase


  Protein function

Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. May be involved in cell-cell interactions.

  Database links

Uniprot primary ID P04058
PDB ID 5BWB 5BWC 1GPK 1GPN 2VT7 1EEA 2V97 1ZGB 1ZGC 2CKM 2V98 2W6C 2XI4 2V96 1H23 1H22 1JGA 2J4F 2VJA 2C4H 3ZV7 4W63 2BAG 2WG0 1W4L 1JGB 1OCE 3I6Z 2C58 1VXO 1VOT 1GQR 1VXR 2VT6 2VJB 2VJC 3I6M 2C5F 2C5G 2VJD 2J3Q 1GQS 2W9I 4TVK 2J3D 1ODC 1EA5 2WG1 2WG2 1AMN 4ACE
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID
PharmGKB ID
KEGG ID
DIP ID
STRING ID
IntAct ID
DMDM
BRENDA 3.1.1.7
Reactome
SignaLink
BioCyc MetaCyc:MONOMER-16823
Entrez Gene (Gene ID)
BindingDB P04058

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.773 0.007 0.883 0.010 0.828 0.004 0.815 0.007 0.900 0.000 0.656 0.008 Download
Estate fingerprints 0.630 0.009 0.804 0.005 0.717 0.007 0.690 0.007 0.815 0.005 0.440 0.014 Download
MACCS fingerprints 0.727 0.012 0.807 0.003 0.767 0.011 0.757 0.011 0.836 0.005 0.540 0.019 Download
Daylight fingerprints 0.781 0.037 0.895 0.017 0.838 0.023 0.827 0.028 0.905 0.012 0.679 0.043 Download
ECFP2 fingerprints 0.859 0.003 0.879 0.005 0.869 0.003 0.863 0.005 0.939 0.003 0.732 0.006 Download
ECFP4 fingerprints 0.872 0.009 0.932 0.007 0.902 0.004 0.899 0.003 0.959 0.003 0.804 0.007 Download
ECFP6 fingerprints 0.859 0.003 0.955 0.004 0.907 0.005 0.900 0.005 0.958 0.004 0.817 0.008 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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