Target name

P04150: Glucocorticoid receptor


  Protein function

Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic genes expression.

  Database links

Uniprot primary ID P04150
PDB ID 3BQD 4HN5 1NHZ 3H52 1M2Z 3CLD 4LSJ 4P6X 1P93 3E7C 4MDD 4CSJ 4HN6 3K22 3K23 4P6W
DrugBank ID DB01380 DB01384 DB00324 DB01410 DB00223 DB00896 DB00596
BioGrid ID 109165
GuidetoPHARMACOLOGY ID 625
PharmGKB ID PA181
KEGG ID hsa:2908
DIP ID DIP-576N
STRING ID 9606.ENSP00000231509
IntAct ID P04150
DMDM 121069
BRENDA
Reactome R-HSA-383280 R-HSA-1368108
SignaLink P04150
BioCyc
Entrez Gene (Gene ID) 2908
BindingDB P04150

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.721 0.003 0.939 0.000 0.830 0.000 0.810 0.000 0.940 0.000 0.680 0.000 Download
Estate fingerprints 0.770 0.000 0.810 0.004 0.790 0.000 0.787 0.005 0.870 0.000 0.580 0.000 Download
MACCS fingerprints 0.842 0.004 0.878 0.000 0.860 0.000 0.856 0.005 0.920 0.000 0.711 0.003 Download
Daylight fingerprints 0.801 0.003 0.779 0.003 0.790 0.000 0.793 0.005 0.830 0.000 0.583 0.005 Download
ECFP2 fingerprints 0.881 0.003 0.961 0.004 0.921 0.003 0.920 0.000 0.980 0.000 0.850 0.000 Download
ECFP4 fingerprints 0.891 0.003 0.989 0.000 0.940 0.000 0.940 0.000 0.990 0.000 0.889 0.003 Download
ECFP6 fingerprints 0.870 0.000 0.990 0.003 0.930 0.000 0.929 0.003 0.990 0.000 0.870 0.000 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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