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E-mail: biomed@csu.edu.cn
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Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic genes expression.
| Uniprot primary ID | P04150 |
| PDB ID | 3BQD 4HN5 1NHZ 3H52 1M2Z 3CLD 4LSJ 4P6X 1P93 3E7C 4MDD 4CSJ 4HN6 3K22 3K23 4P6W |
| DrugBank ID | DB01380 DB01384 DB00324 DB01410 DB00223 DB00896 DB00596 |
| BioGrid ID | 109165 |
| GuidetoPHARMACOLOGY ID | 625 |
| PharmGKB ID | PA181 |
| KEGG ID | hsa:2908 |
| DIP ID | DIP-576N |
| STRING ID | 9606.ENSP00000231509 |
| IntAct ID | P04150 |
| DMDM | 121069 |
| BRENDA | |
| Reactome | R-HSA-383280 R-HSA-1368108 |
| SignaLink | P04150 |
| BioCyc | |
| Entrez Gene (Gene ID) | 2908 |
| BindingDB | P04150 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.721 | 0.003 | 0.939 | 0.000 | 0.830 | 0.000 | 0.810 | 0.000 | 0.940 | 0.000 | 0.680 | 0.000 | Download |
| Estate fingerprints | 0.770 | 0.000 | 0.810 | 0.004 | 0.790 | 0.000 | 0.787 | 0.005 | 0.870 | 0.000 | 0.580 | 0.000 | Download |
| MACCS fingerprints | 0.842 | 0.004 | 0.878 | 0.000 | 0.860 | 0.000 | 0.856 | 0.005 | 0.920 | 0.000 | 0.711 | 0.003 | Download |
| Daylight fingerprints | 0.801 | 0.003 | 0.779 | 0.003 | 0.790 | 0.000 | 0.793 | 0.005 | 0.830 | 0.000 | 0.583 | 0.005 | Download |
| ECFP2 fingerprints | 0.881 | 0.003 | 0.961 | 0.004 | 0.921 | 0.003 | 0.920 | 0.000 | 0.980 | 0.000 | 0.850 | 0.000 | Download |
| ECFP4 fingerprints | 0.891 | 0.003 | 0.989 | 0.000 | 0.940 | 0.000 | 0.940 | 0.000 | 0.990 | 0.000 | 0.889 | 0.003 | Download |
| ECFP6 fingerprints | 0.870 | 0.000 | 0.990 | 0.003 | 0.930 | 0.000 | 0.929 | 0.003 | 0.990 | 0.000 | 0.870 | 0.000 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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