Target name

P04818: Thymidylate synthase


  Protein function

Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.

  Database links

Uniprot primary ID P04818
PDB ID 3GH2 3GH0 3ED7 2ONB 3EF9 3H9K 3EJL 3EBU 4UP1 4E28 3EHI 3HB8 4G2O 2RD8 3GG5 1JU6 3EAW 3OB7 1YPV 4O1X 1HVY 4O1U 4FGT 4GD7 1I00 3N5E 3N5G 1JUJ 4JEF 3EGY 2RDA 1HW3 1HW4 3EDW 4G6W 4H1I 4KPW 1HZW 4GYH
DrugBank ID DB00650 DB00563 DB01101 DB00441 DB00440 DB00322 DB00293
BioGrid ID 113149
GuidetoPHARMACOLOGY ID 2642
PharmGKB ID PA359
KEGG ID hsa:7298
DIP ID
STRING ID 9606.ENSP00000315644
IntAct ID P04818
DMDM 136611
BRENDA 2.1.1.45
Reactome R-HSA-113510 R-HSA-69205 R-HSA-500753
SignaLink
BioCyc MetaCyc:HS11096-MONOMER
Entrez Gene (Gene ID) 7298
BindingDB P04818

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.873 0.005 0.977 0.000 0.925 0.005 0.920 0.000 0.978 0.004 0.855 0.005 Download
Estate fingerprints 0.801 0.003 0.841 0.006 0.821 0.003 0.819 0.003 0.910 0.000 0.645 0.007 Download
MACCS fingerprints 0.791 0.007 0.911 0.007 0.851 0.006 0.841 0.006 0.930 0.000 0.708 0.009 Download
Daylight fingerprints 0.770 0.000 0.998 0.000 0.884 0.005 0.870 0.000 0.950 0.000 0.790 0.000 Download
ECFP2 fingerprints 0.919 0.003 0.971 0.000 0.945 0.005 0.943 0.005 0.990 0.000 0.890 0.005 Download
ECFP4 fingerprints 0.945 0.005 0.989 0.000 0.967 0.005 0.967 0.005 0.990 0.000 0.935 0.005 Download
ECFP6 fingerprints 0.920 0.000 1.000 0.000 0.960 0.000 0.957 0.005 0.990 0.000 0.920 0.000 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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