Target name

P05067: Amyloid beta A4 protein


  Protein function

Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1.

  Database links

Uniprot primary ID P05067
PDB ID 4JFN 2MVX 2MXU 5CSZ 3SV1 4NGE 2Y3K 1OWT 1TAW 2MPZ 3L81 2M4J 3AYU 1BA6 2FK3 1BA4 1CA0 3NYL 3JQL 3BAE 1MWP 2BP4 3UMI 3UMH 3UMK 4MVK 2LMO 2LMN 2FK1 2IPU 1QCM 2FK2 3JQ5 2LZ3 2LZ4 2R0W 1IYT 2FKL 3NYJ 4OJF 2LMQ 2LMP 2G47 1ZE9 1ZE7 4MVL 3U0T 2MGT 2M9S 2FJZ 3OVJ
DrugBank ID
BioGrid ID 106848
GuidetoPHARMACOLOGY ID
PharmGKB ID PA24910
KEGG ID hsa:351
DIP ID DIP-574N
STRING ID 9606.ENSP00000284981
IntAct ID P05067
DMDM 112927
BRENDA
Reactome R-HSA-444473 R-HSA-933542 R-HSA-3134963 R-HSA-432720 R-HSA-114608 R-HSA-418594 R-HSA-844456 R-HSA-416476 R-HSA-3000178 R-HSA-445989 R-HSA-1810476 R-HSA-977225 R-HSA-879415
SignaLink
BioCyc MetaCyc:ENSG00000142192-MONOMER
Entrez Gene (Gene ID) 351
BindingDB P05067

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.817 0.007 0.923 0.008 0.870 0.007 0.863 0.005 0.953 0.005 0.744 0.011 Download
Estate fingerprints 0.769 0.014 0.785 0.007 0.777 0.008 0.776 0.010 0.850 0.000 0.556 0.015 Download
MACCS fingerprints 0.848 0.008 0.794 0.011 0.821 0.006 0.827 0.007 0.869 0.003 0.643 0.008 Download
Daylight fingerprints 0.706 0.008 0.850 0.004 0.778 0.004 0.762 0.006 0.830 0.000 0.562 0.006 Download
ECFP2 fingerprints 0.952 0.010 0.912 0.004 0.932 0.006 0.936 0.007 0.980 0.000 0.869 0.010 Download
ECFP4 fingerprints 0.962 0.006 0.940 0.005 0.951 0.003 0.952 0.004 0.990 0.000 0.909 0.006 Download
ECFP6 fingerprints 0.950 0.005 0.986 0.000 0.968 0.004 0.968 0.004 0.990 0.000 0.933 0.007 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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