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E-mail: biomed@csu.edu.cn
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Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty.
| Uniprot primary ID | P05093 |
| PDB ID | 4NKW 3SWZ 4NKZ 4NKY 4NKX 3RUK 2C17 4NKV |
| DrugBank ID | DB01424 DB01234 DB05812 DB01233 DB00396 |
| BioGrid ID | 107958 |
| GuidetoPHARMACOLOGY ID | 1361 |
| PharmGKB ID | PA27090 |
| KEGG ID | hsa:1586 |
| DIP ID | |
| STRING ID | 9606.ENSP00000358903 |
| IntAct ID | P05093 |
| DMDM | 117283 |
| BRENDA | 1.14.99.9 |
| Reactome | R-HSA-193048 R-HSA-194002 R-HSA-211976 R-HSA-5579028 |
| SignaLink | |
| BioCyc | MetaCyc:HS07560-MONOMER |
| Entrez Gene (Gene ID) | 1586 |
| BindingDB | P05093 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.950 | 0.000 | 0.942 | 0.005 | 0.946 | 0.005 | 0.946 | 0.005 | 0.980 | 0.000 | 0.891 | 0.003 | Download |
| Estate fingerprints | 0.893 | 0.005 | 0.889 | 0.005 | 0.891 | 0.003 | 0.891 | 0.003 | 0.950 | 0.000 | 0.779 | 0.006 | Download |
| MACCS fingerprints | 0.941 | 0.003 | 0.873 | 0.005 | 0.907 | 0.005 | 0.910 | 0.000 | 0.967 | 0.005 | 0.816 | 0.007 | Download |
| Daylight fingerprints | 0.813 | 0.008 | 0.827 | 0.000 | 0.820 | 0.005 | 0.819 | 0.006 | 0.880 | 0.000 | 0.640 | 0.007 | Download |
| ECFP2 fingerprints | 1.000 | 0.000 | 0.958 | 0.004 | 0.979 | 0.003 | 0.979 | 0.003 | 1.000 | 0.000 | 0.954 | 0.007 | Download |
| ECFP4 fingerprints | 0.990 | 0.000 | 0.978 | 0.005 | 0.984 | 0.005 | 0.984 | 0.005 | 1.000 | 0.000 | 0.966 | 0.007 | Download |
| ECFP6 fingerprints | 0.975 | 0.007 | 0.983 | 0.000 | 0.979 | 0.003 | 0.979 | 0.003 | 1.000 | 0.000 | 0.953 | 0.007 | Download |
| Positive dataset | Negative dataset |
The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
E-mail: biomed@csu.edu.cn
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