Target name

P05093: Steroid 17-alpha-hydroxylase/17,20 lyase


  Protein function

Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty.

  Database links

Uniprot primary ID P05093
PDB ID 4NKW 3SWZ 4NKZ 4NKY 4NKX 3RUK 2C17 4NKV
DrugBank ID DB01424 DB01234 DB05812 DB01233 DB00396
BioGrid ID 107958
GuidetoPHARMACOLOGY ID 1361
PharmGKB ID PA27090
KEGG ID hsa:1586
DIP ID
STRING ID 9606.ENSP00000358903
IntAct ID P05093
DMDM 117283
BRENDA 1.14.99.9
Reactome R-HSA-193048 R-HSA-194002 R-HSA-211976 R-HSA-5579028
SignaLink
BioCyc MetaCyc:HS07560-MONOMER
Entrez Gene (Gene ID) 1586
BindingDB P05093

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.950 0.000 0.942 0.005 0.946 0.005 0.946 0.005 0.980 0.000 0.891 0.003 Download
Estate fingerprints 0.893 0.005 0.889 0.005 0.891 0.003 0.891 0.003 0.950 0.000 0.779 0.006 Download
MACCS fingerprints 0.941 0.003 0.873 0.005 0.907 0.005 0.910 0.000 0.967 0.005 0.816 0.007 Download
Daylight fingerprints 0.813 0.008 0.827 0.000 0.820 0.005 0.819 0.006 0.880 0.000 0.640 0.007 Download
ECFP2 fingerprints 1.000 0.000 0.958 0.004 0.979 0.003 0.979 0.003 1.000 0.000 0.954 0.007 Download
ECFP4 fingerprints 0.990 0.000 0.978 0.005 0.984 0.005 0.984 0.005 1.000 0.000 0.966 0.007 Download
ECFP6 fingerprints 0.975 0.007 0.983 0.000 0.979 0.003 0.979 0.003 1.000 0.000 0.953 0.007 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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