Target name

P05106: Integrin beta-3


  Protein function

Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets (By similarity).

  Database links

Uniprot primary ID P05106
PDB ID 1MK7 2K9J 2LJD 2LJE 2LJF 1M8O 3ZE0 3ZE1 3ZE2 1KUP 2VDQ 2MTP 2RMZ 4CAK 4MMZ 3NIF 1MIZ 3T3P 3IJE 2RN0 2INI 3T3M 1U8C 2L1C 1L5G 1S4X 2VDK 2VDL 2VDM 2VDN 2VDO 1KUZ 3FCU 2KNC 3FCS 1MK9 2L91 1RN0 3ZDZ 2VDP 3NID 2VDR 1JV2 1M1X 4G1E 3ZDX 1TYE 4MMX 4G1M 3NIG 4O02
DrugBank ID DB00098 DB00054 DB00063 DB00775
BioGrid ID 109896
GuidetoPHARMACOLOGY ID
PharmGKB ID PA205
KEGG ID hsa:3690
DIP ID DIP-304N
STRING ID 9606.ENSP00000262017
IntAct ID P05106
DMDM 125987835
BRENDA
Reactome R-HSA-216083 R-HSA-4420097 R-HSA-2129379 R-HSA-114608 R-HSA-1566948 R-HSA-354194 R-HSA-354192 R-HSA-3000178 R-HSA-372708 R-HSA-445144 R-HSA-5674135 R-HSA-210990 R-HSA-3000170
SignaLink P05106
BioCyc
Entrez Gene (Gene ID) 3690
BindingDB P05106

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.931 0.003 0.969 0.000 0.950 0.000 0.950 0.000 0.990 0.000 0.900 0.000 Download
Estate fingerprints 0.970 0.000 0.870 0.000 0.920 0.000 0.920 0.000 0.960 0.000 0.843 0.005 Download
MACCS fingerprints 0.934 0.005 0.906 0.000 0.920 0.000 0.920 0.000 0.970 0.000 0.839 0.003 Download
Daylight fingerprints 0.936 0.005 0.944 0.000 0.940 0.000 0.940 0.000 0.960 0.000 0.884 0.005 Download
ECFP2 fingerprints 0.987 0.005 0.973 0.000 0.980 0.000 0.980 0.000 1.000 0.000 0.957 0.005 Download
ECFP4 fingerprints 0.980 0.000 0.982 0.000 0.981 0.003 0.981 0.003 1.000 0.000 0.970 0.000 Download
ECFP6 fingerprints 0.970 0.000 0.990 0.003 0.980 0.000 0.980 0.000 1.000 0.000 0.962 0.004 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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