TargetNet
  Target name

P05121: Plasminogen activator inhibitor 1

  Protein function

Serine protease inhibitor. This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis.

  Database links
Uniprot primary ID P05121
PDB ID 4IC0 3CVM 3Q03 1DB2 1A7C 3UT3 1C5G 4G8R 3Q02 3EOX 4G8O 1OC0 9PAI 1DVN 1LJ5 3PB1 3R4L 5BRR 1B3K 1DVM 4AQH
DrugBank ID DB00031 DB00055 DB00009 DB00013 DB00029 DB00015
BioGrid ID 111091
GuidetoPHARMACOLOGY ID
PharmGKB ID PA261
KEGG ID hsa:5054
DIP ID
STRING ID 9606.ENSP00000223095
IntAct ID P05121
DMDM 129576
BRENDA
Reactome R-HSA-3000178 R-HSA-75205 R-HSA-1368108 R-HSA-114608 R-HSA-2173796
SignaLink
BioCyc
Entrez Gene (Gene ID) 5054
BindingDB P05121
  Model Performance Metrics
Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.921 0.009 0.957 0.005 0.939 0.006 0.939 0.006 0.980 0.000 0.880 0.009 Download
Estate fingerprints 0.889 0.009 0.843 0.010 0.866 0.007 0.868 0.006 0.950 0.000 0.730 0.012 Download
MACCS fingerprints 0.894 0.007 0.866 0.005 0.880 0.000 0.882 0.004 0.955 0.005 0.760 0.007 Download
Daylight fingerprints 0.818 0.006 0.958 0.007 0.888 0.004 0.881 0.007 0.919 0.003 0.789 0.011 Download
ECFP2 fingerprints 0.931 0.007 0.967 0.009 0.949 0.006 0.949 0.006 0.990 0.000 0.899 0.011 Download
ECFP4 fingerprints 0.937 0.007 0.987 0.005 0.962 0.006 0.960 0.005 0.991 0.003 0.925 0.012 Download
ECFP6 fingerprints 0.899 0.014 0.995 0.000 0.947 0.007 0.942 0.008 0.995 0.005 0.896 0.012 Download
  Download datasets
Positive dataset Negative dataset

The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
 E-mail: biomed@csu.edu.cn