ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation.
| Uniprot primary ID | P05362 |
| PDB ID | 2OZ4 1IAM 1D3L 1D3I 3TCX 1IC1 1D3E 1P53 1Z7Z 1IJ4 1MQ8 |
| DrugBank ID | DB08818 DB00108 |
| BioGrid ID | 109610 |
| GuidetoPHARMACOLOGY ID | |
| PharmGKB ID | PA29592 |
| KEGG ID | hsa:3383 |
| DIP ID | DIP-36658N |
| STRING ID | 9606.ENSP00000264832 |
| IntAct ID | P05362 |
| DMDM | 68067956 |
| BRENDA | |
| Reactome | R-HSA-216083 R-HSA-877300 R-HSA-198933 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 3383 |
| BindingDB | P05362 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.832 | 0.006 | 0.988 | 0.003 | 0.910 | 0.000 | 0.902 | 0.004 | 0.987 | 0.005 | 0.831 | 0.006 | Download |
| Estate fingerprints | 0.802 | 0.006 | 0.838 | 0.005 | 0.820 | 0.000 | 0.816 | 0.005 | 0.903 | 0.005 | 0.637 | 0.005 | Download |
| MACCS fingerprints | 0.874 | 0.008 | 0.860 | 0.009 | 0.867 | 0.005 | 0.868 | 0.004 | 0.938 | 0.004 | 0.735 | 0.005 | Download |
| Daylight fingerprints | 0.759 | 0.007 | 1.000 | 0.003 | 0.880 | 0.005 | 0.863 | 0.005 | 0.960 | 0.000 | 0.780 | 0.007 | Download |
| ECFP2 fingerprints | 0.940 | 0.007 | 0.974 | 0.003 | 0.957 | 0.005 | 0.956 | 0.005 | 0.990 | 0.000 | 0.915 | 0.005 | Download |
| ECFP4 fingerprints | 0.980 | 0.005 | 0.994 | 0.000 | 0.987 | 0.005 | 0.987 | 0.005 | 1.000 | 0.000 | 0.971 | 0.006 | Download |
| ECFP6 fingerprints | 0.952 | 0.004 | 0.998 | 0.004 | 0.975 | 0.005 | 0.975 | 0.005 | 1.000 | 0.000 | 0.950 | 0.005 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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