Target name

P05362: Intercellular adhesion molecule 1


  Protein function

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation.

  Database links

Uniprot primary ID P05362
PDB ID 2OZ4 1IAM 1D3L 1D3I 3TCX 1IC1 1D3E 1P53 1Z7Z 1IJ4 1MQ8
DrugBank ID DB08818 DB00108
BioGrid ID 109610
GuidetoPHARMACOLOGY ID
PharmGKB ID PA29592
KEGG ID hsa:3383
DIP ID DIP-36658N
STRING ID 9606.ENSP00000264832
IntAct ID P05362
DMDM 68067956
BRENDA
Reactome R-HSA-216083 R-HSA-877300 R-HSA-198933
SignaLink
BioCyc
Entrez Gene (Gene ID) 3383
BindingDB P05362

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.832 0.006 0.988 0.003 0.910 0.000 0.902 0.004 0.987 0.005 0.831 0.006 Download
Estate fingerprints 0.802 0.006 0.838 0.005 0.820 0.000 0.816 0.005 0.903 0.005 0.637 0.005 Download
MACCS fingerprints 0.874 0.008 0.860 0.009 0.867 0.005 0.868 0.004 0.938 0.004 0.735 0.005 Download
Daylight fingerprints 0.759 0.007 1.000 0.003 0.880 0.005 0.863 0.005 0.960 0.000 0.780 0.007 Download
ECFP2 fingerprints 0.940 0.007 0.974 0.003 0.957 0.005 0.956 0.005 0.990 0.000 0.915 0.005 Download
ECFP4 fingerprints 0.980 0.005 0.994 0.000 0.987 0.005 0.987 0.005 1.000 0.000 0.971 0.006 Download
ECFP6 fingerprints 0.952 0.004 0.998 0.004 0.975 0.005 0.975 0.005 1.000 0.000 0.950 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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