Target name

P05364: Beta-lactamase


  Protein function

This protein is a serine beta-lactamase with a substrate specificity for cephalosporins.

  Database links

Uniprot primary ID P05364
PDB ID 3S4X 1BLS 2Q9M 2Q9N 1Y54 1RGZ 4XUX 1GCE 1XX2
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID
PharmGKB ID
KEGG ID
DIP ID
STRING ID 718254.ENC_42520
IntAct ID
DMDM
BRENDA 3.5.2.6
Reactome
SignaLink
BioCyc
Entrez Gene (Gene ID)
BindingDB P05364

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.705 0.008 1.000 0.000 0.853 0.005 0.832 0.004 0.990 0.000 0.742 0.004 Download
Estate fingerprints 0.912 0.010 0.908 0.011 0.910 0.007 0.910 0.007 0.970 0.000 0.817 0.013 Download
MACCS fingerprints 0.915 0.010 0.945 0.004 0.930 0.007 0.927 0.007 0.986 0.005 0.857 0.013 Download
Daylight fingerprints 0.638 0.004 0.932 0.008 0.785 0.008 0.749 0.006 0.834 0.007 0.595 0.013 Download
ECFP2 fingerprints 0.932 0.009 0.998 0.000 0.965 0.005 0.965 0.005 1.000 0.000 0.936 0.013 Download
ECFP4 fingerprints 0.953 0.012 0.989 0.007 0.971 0.010 0.971 0.010 1.000 0.000 0.943 0.016 Download
ECFP6 fingerprints 0.941 0.010 0.991 0.000 0.966 0.007 0.966 0.007 1.000 0.000 0.938 0.014 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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