Target name

P06239: Tyrosine-protein kinase Lck


  Protein function

Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosines residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the cytoplasmic tails of the TCR-gamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. Once stimulated, the TCR recruits the tyrosine kinase ZAP70, that becomes phosphorylated and activated by LCK. Following this, a large number of signaling molecules are recruited, ultimately leading to lymphokine production. LCK also contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, which leads to hyperphosphorylation and activation of LCK. Also plays a role in the IL2 receptor-linked signaling pathway that controls the T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK. Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature alpha beta TCR. Phosphorylates other substrates including RUNX3, PTK2B/PYK2, the microtubule-associated protein MAPT, RHOH or TYROBP.

  Database links

Uniprot primary ID P06239
PDB ID 4C3F 3BYU 1X27 2ZM4 1KIK 3MPM 2ZM1 3BYS 3AC1 3BYM 3BYO 3AD4 3AD5 3AD6 2OG8 1QPC 1FBZ 1Q68 1Q69 3ACK 3ACJ 2ZYB 1BHF 1CWE 1CWD 2OFU 1BHH 2OFV 1QPD 1QPE 3BRH 1LKL 1QPJ 1LKK 1H92 3AC5 2OF2 1LCJ 1LCK 3AC3 2OF4 1IJR 3AC8 4D8K 3AC4 2PL0 3AC2 2IIM 3KMM 3KXZ 3B2W
DrugBank ID DB01254 DB08901 DB09079
BioGrid ID 110124
GuidetoPHARMACOLOGY ID 2053
PharmGKB ID PA30307
KEGG ID hsa:3932
DIP ID DIP-553N
STRING ID 9606.ENSP00000337825
IntAct ID P06239
DMDM 125474
BRENDA 2.7.10.2
Reactome R-HSA-202433 R-HSA-389948 R-HSA-1433559 R-HSA-167590 R-HSA-1257604 R-HSA-202427 R-HSA-114604 R-HSA-210990 R-HSA-451927 R-HSA-1433557 R-HSA-2219530 R-HSA-389513 R-HSA-202430 R-HSA-2424491 R-HSA-389356 R-HSA-389357 R-HSA-202424 R-HSA-389359 R-HSA-164944
SignaLink P06239
BioCyc
Entrez Gene (Gene ID) 3932
BindingDB P06239

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.840 0.000 0.842 0.000 0.841 0.003 0.840 0.000 0.896 0.005 0.690 0.000 Download
Estate fingerprints 0.825 0.005 0.755 0.000 0.790 0.000 0.798 0.004 0.850 0.000 0.579 0.003 Download
MACCS fingerprints 0.832 0.004 0.728 0.004 0.780 0.000 0.790 0.000 0.850 0.000 0.560 0.000 Download
Daylight fingerprints 0.840 0.000 0.756 0.000 0.798 0.004 0.806 0.005 0.829 0.003 0.597 0.005 Download
ECFP2 fingerprints 0.860 0.000 0.842 0.000 0.851 0.003 0.852 0.004 0.923 0.005 0.706 0.005 Download
ECFP4 fingerprints 0.840 0.000 0.940 0.000 0.890 0.000 0.880 0.000 0.950 0.000 0.780 0.000 Download
ECFP6 fingerprints 0.811 0.003 0.949 0.000 0.880 0.000 0.871 0.003 0.950 0.000 0.770 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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