Target name

P06401: Progesterone receptor


  Protein function

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation.

  Database links

Uniprot primary ID P06401
PDB ID 2OVM 4A2J 3ZR7 4APU 1SR7 1SQN 3HQ5 2W8Y 1ZUC 3G8O 1A28 3ZRA 3D90 3ZRB 3KBA 2OVH 1E3K 2C7A 4OAR
DrugBank ID DB00588 DB06713 DB00957 DB00823 DB01395 DB00294 DB00396
BioGrid ID 111260
GuidetoPHARMACOLOGY ID 627
PharmGKB ID PA266
KEGG ID hsa:5241
DIP ID DIP-5967N
STRING ID 9606.ENSP00000325120
IntAct ID P06401
DMDM 90110048
BRENDA
Reactome R-HSA-383280 R-HSA-1251985
SignaLink P06401
BioCyc
Entrez Gene (Gene ID) 5241
BindingDB

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.730 0.000 0.966 0.000 0.848 0.004 0.824 0.005 0.940 0.000 0.710 0.000 Download
Estate fingerprints 0.845 0.005 0.843 0.003 0.844 0.005 0.841 0.003 0.910 0.000 0.690 0.000 Download
MACCS fingerprints 0.799 0.003 0.861 0.003 0.830 0.000 0.820 0.000 0.910 0.000 0.659 0.003 Download
Daylight fingerprints 0.741 0.003 0.841 0.000 0.791 0.003 0.780 0.000 0.840 0.000 0.591 0.003 Download
ECFP2 fingerprints 0.920 0.000 0.956 0.000 0.938 0.004 0.931 0.003 0.990 0.000 0.871 0.003 Download
ECFP4 fingerprints 0.928 0.004 0.974 0.000 0.951 0.003 0.950 0.000 0.990 0.000 0.910 0.000 Download
ECFP6 fingerprints 0.896 0.005 0.984 0.000 0.940 0.000 0.937 0.005 0.990 0.000 0.881 0.003 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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