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E-mail: biomed@csu.edu.cn
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The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands.
| Uniprot primary ID | P06756 |
| PDB ID | 1JV2 1L5G 4MMZ 4MMX 4MMY 4G1M 4O02 4G1E 1U8C 3IJE 1M1X 4UM8 4UM9 |
| DrugBank ID | DB00098 |
| BioGrid ID | 109891 |
| GuidetoPHARMACOLOGY ID | |
| PharmGKB ID | PA37336 |
| KEGG ID | hsa:3685 |
| DIP ID | DIP-31785N |
| STRING ID | 9606.ENSP00000261023 |
| IntAct ID | P06756 |
| DMDM | 143811408 |
| BRENDA | |
| Reactome | R-HSA-216083 R-HSA-4420097 R-HSA-2129379 R-HSA-3000157 R-HSA-1566948 R-HSA-1236973 R-HSA-3000178 R-HSA-445144 R-HSA-210990 R-HSA-3000170 |
| SignaLink | P06756 |
| BioCyc | |
| Entrez Gene (Gene ID) | 3685 |
| BindingDB | P06756 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.928 | 0.004 | 0.948 | 0.005 | 0.938 | 0.004 | 0.936 | 0.005 | 0.980 | 0.000 | 0.872 | 0.004 | Download |
| Estate fingerprints | 0.960 | 0.000 | 0.880 | 0.005 | 0.920 | 0.000 | 0.920 | 0.000 | 0.960 | 0.000 | 0.839 | 0.003 | Download |
| MACCS fingerprints | 0.930 | 0.000 | 0.890 | 0.004 | 0.910 | 0.000 | 0.910 | 0.000 | 0.970 | 0.000 | 0.820 | 0.000 | Download |
| Daylight fingerprints | 0.918 | 0.004 | 0.922 | 0.005 | 0.920 | 0.000 | 0.920 | 0.000 | 0.950 | 0.000 | 0.843 | 0.005 | Download |
| ECFP2 fingerprints | 0.980 | 0.000 | 0.960 | 0.000 | 0.970 | 0.000 | 0.970 | 0.000 | 0.991 | 0.003 | 0.939 | 0.003 | Download |
| ECFP4 fingerprints | 0.970 | 0.000 | 0.990 | 0.000 | 0.980 | 0.000 | 0.980 | 0.000 | 1.000 | 0.000 | 0.960 | 0.000 | Download |
| ECFP6 fingerprints | 0.970 | 0.000 | 0.990 | 0.000 | 0.980 | 0.000 | 0.980 | 0.000 | 0.993 | 0.005 | 0.960 | 0.000 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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