Target name

P06756: Integrin alpha-V


  Protein function

The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands.

  Database links

Uniprot primary ID P06756
PDB ID 1JV2 1L5G 4MMZ 4MMX 4MMY 4G1M 4O02 4G1E 1U8C 3IJE 1M1X 4UM8 4UM9
DrugBank ID DB00098
BioGrid ID 109891
GuidetoPHARMACOLOGY ID
PharmGKB ID PA37336
KEGG ID hsa:3685
DIP ID DIP-31785N
STRING ID 9606.ENSP00000261023
IntAct ID P06756
DMDM 143811408
BRENDA
Reactome R-HSA-216083 R-HSA-4420097 R-HSA-2129379 R-HSA-3000157 R-HSA-1566948 R-HSA-1236973 R-HSA-3000178 R-HSA-445144 R-HSA-210990 R-HSA-3000170
SignaLink P06756
BioCyc
Entrez Gene (Gene ID) 3685
BindingDB P06756

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.928 0.004 0.948 0.005 0.938 0.004 0.936 0.005 0.980 0.000 0.872 0.004 Download
Estate fingerprints 0.960 0.000 0.880 0.005 0.920 0.000 0.920 0.000 0.960 0.000 0.839 0.003 Download
MACCS fingerprints 0.930 0.000 0.890 0.004 0.910 0.000 0.910 0.000 0.970 0.000 0.820 0.000 Download
Daylight fingerprints 0.918 0.004 0.922 0.005 0.920 0.000 0.920 0.000 0.950 0.000 0.843 0.005 Download
ECFP2 fingerprints 0.980 0.000 0.960 0.000 0.970 0.000 0.970 0.000 0.991 0.003 0.939 0.003 Download
ECFP4 fingerprints 0.970 0.000 0.990 0.000 0.980 0.000 0.980 0.000 1.000 0.000 0.960 0.000 Download
ECFP6 fingerprints 0.970 0.000 0.990 0.000 0.980 0.000 0.980 0.000 0.993 0.005 0.960 0.000 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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