Target name

P07308: Acyl-CoA desaturase 1


  Protein function

Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates (PubMed:2892838, PubMed:7947684). Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:2892838, PubMed:7947684). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids. Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation (By similarity). Plays an important role in body energy homeostasis (By similarity). Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides (PubMed:7947684). Required for normal development of sebaceous glands. Required for the biosynthesis of normal levels of delta-9 unsaturated fatty acids and 1-alkyl-2,3-diacylglycerol in the Harderian gland. Required for normal production of meibum, an oily material that prevents drying of the cornea (By similarity).

  Database links

Uniprot primary ID P07308
PDB ID
DrugBank ID
BioGrid ID 251497
GuidetoPHARMACOLOGY ID
PharmGKB ID
KEGG ID rno:246074
DIP ID
STRING ID 10116.ENSRNOP00000018447
IntAct ID
DMDM
BRENDA 1.14.19.1
Reactome
SignaLink
BioCyc MetaCyc:MONOMER-14123
Entrez Gene (Gene ID) 246074
BindingDB P07308

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.895 0.010 0.937 0.004 0.916 0.007 0.914 0.007 0.979 0.003 0.832 0.012 Download
Estate fingerprints 0.795 0.008 0.815 0.007 0.805 0.005 0.804 0.007 0.890 0.000 0.604 0.011 Download
MACCS fingerprints 0.785 0.008 0.817 0.007 0.801 0.007 0.797 0.007 0.910 0.000 0.601 0.014 Download
Daylight fingerprints 0.880 0.009 0.972 0.004 0.926 0.007 0.922 0.008 0.981 0.003 0.855 0.012 Download
ECFP2 fingerprints 0.975 0.007 0.929 0.007 0.952 0.004 0.952 0.004 0.990 0.000 0.906 0.010 Download
ECFP4 fingerprints 0.989 0.003 0.973 0.003 0.981 0.003 0.981 0.003 1.000 0.000 0.964 0.005 Download
ECFP6 fingerprints 0.971 0.006 0.993 0.000 0.982 0.004 0.982 0.004 1.000 0.000 0.965 0.007 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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