Target name

P07333: Macrophage colony-stimulating factor 1 receptor


  Protein function

Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion. Activates several signaling pathways in response to ligand binding. Phosphorylates PIK3R1, PLCG2, GRB2, SLA2 and CBL. Activation of PLCG2 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, that then lead to the activation of protein kinase C family members, especially PRKCD. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to activation of the AKT1 signaling pathway. Activated CSF1R also mediates activation of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1, and of the SRC family kinases SRC, FYN and YES1. Activated CSF1R transmits signals both via proteins that directly interact with phosphorylated tyrosine residues in its intracellular domain, or via adapter proteins, such as GRB2. Promotes activation of STAT family members STAT3, STAT5A and/or STAT5B. Promotes tyrosine phosphorylation of SHC1 and INPP5D/SHIP-1. Receptor signaling is down-regulated by protein phosphatases, such as INPP5D/SHIP-1, that dephosphorylate the receptor and its downstream effectors, and by rapid internalization of the activated receptor.

  Database links

Uniprot primary ID P07333
PDB ID 3KRJ 3KRL 2I0Y 4DKD 2I1M 4WRM 4WRL 4HW7 3LCD 2I0V 2OGV 3BEA 4R7I 4R7H 3DPK 4LIQ 3LCO
DrugBank ID DB00619 DB01268
BioGrid ID 107823
GuidetoPHARMACOLOGY ID 1806
PharmGKB ID PA26936
KEGG ID hsa:1436
DIP ID DIP-59421N
STRING ID 9606.ENSP00000286301
IntAct ID P07333
DMDM 547770
BRENDA 2.7.10.1
Reactome
SignaLink P07333
BioCyc
Entrez Gene (Gene ID) 1436
BindingDB P07333

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.880 0.000 0.912 0.000 0.896 0.005 0.894 0.005 0.950 0.000 0.791 0.006 Download
Estate fingerprints 0.859 0.003 0.781 0.005 0.820 0.000 0.824 0.005 0.910 0.000 0.639 0.006 Download
MACCS fingerprints 0.868 0.004 0.776 0.005 0.822 0.004 0.829 0.003 0.919 0.003 0.648 0.009 Download
Daylight fingerprints 0.831 0.003 0.959 0.004 0.895 0.005 0.888 0.004 0.950 0.000 0.794 0.007 Download
ECFP2 fingerprints 0.911 0.006 0.911 0.003 0.911 0.003 0.911 0.003 0.970 0.000 0.823 0.007 Download
ECFP4 fingerprints 0.896 0.005 0.964 0.003 0.930 0.000 0.928 0.004 0.970 0.000 0.859 0.003 Download
ECFP6 fingerprints 0.855 0.005 0.985 0.000 0.920 0.000 0.910 0.000 0.960 0.000 0.840 0.000 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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