Target name

P07339: Cathepsin D


  Protein function

Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.

  Database links

Uniprot primary ID P07339
PDB ID 1LYA 1LYB 4OBZ 4OC6 4OD9 1LYW
DrugBank ID DB00030
BioGrid ID 107889
GuidetoPHARMACOLOGY ID 2345
PharmGKB ID PA27029
KEGG ID hsa:1509
DIP ID DIP-43906N
STRING ID 9606.ENSP00000236671
IntAct ID P07339
DMDM 115717
BRENDA 3.4.23.5
Reactome R-HSA-1442490 R-HSA-2022377 R-HSA-2132295
SignaLink
BioCyc MetaCyc:HS04183-MONOMER
Entrez Gene (Gene ID) 1509
BindingDB P07339

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.901 0.003 0.879 0.003 0.890 0.000 0.891 0.003 0.950 0.000 0.783 0.005 Download
Estate fingerprints 0.830 0.000 0.770 0.000 0.800 0.000 0.806 0.005 0.890 0.000 0.601 0.003 Download
MACCS fingerprints 0.800 0.000 0.842 0.004 0.821 0.003 0.820 0.000 0.910 0.000 0.650 0.000 Download
Daylight fingerprints 0.880 0.000 0.920 0.000 0.900 0.000 0.893 0.005 0.910 0.000 0.790 0.000 Download
ECFP2 fingerprints 0.920 0.000 0.940 0.000 0.930 0.000 0.930 0.000 0.980 0.000 0.862 0.004 Download
ECFP4 fingerprints 0.921 0.003 0.979 0.004 0.950 0.000 0.950 0.000 0.990 0.000 0.902 0.004 Download
ECFP6 fingerprints 0.897 0.005 0.985 0.000 0.941 0.003 0.940 0.000 0.990 0.000 0.889 0.003 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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