Important for the overall degradation of proteins in lysosomes.
| Uniprot primary ID | P07711 |
| PDB ID | 3IV2 2NQD 3H89 4AXM 1ICF 1CJL 3KSE 3OF8 3OF9 2YJC 2YJB 3HHA 3K24 3BC3 2YJ2 2YJ9 2YJ8 2XU3 2XU5 2XU4 2VHS 1CS8 4AXL 1MHW 3H8C 3H8B 3HWN 2XU1 |
| DrugBank ID | |
| BioGrid ID | 107894 |
| GuidetoPHARMACOLOGY ID | 2351 |
| PharmGKB ID | PA162382890 |
| KEGG ID | hsa:1514 |
| DIP ID | |
| STRING ID | 9606.ENSP00000345344 |
| IntAct ID | P07711 |
| DMDM | 115741 |
| BRENDA | 3.4.22.15 |
| Reactome | R-HSA-1474228 R-HSA-1236977 R-HSA-1442490 R-HSA-1679131 R-HSA-2132295 R-HSA-2022090 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 1514 |
| BindingDB | P07711 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.843 | 0.005 | 0.825 | 0.005 | 0.834 | 0.005 | 0.836 | 0.005 | 0.900 | 0.000 | 0.669 | 0.006 | Download |
| Estate fingerprints | 0.796 | 0.005 | 0.824 | 0.004 | 0.810 | 0.000 | 0.809 | 0.003 | 0.880 | 0.000 | 0.623 | 0.005 | Download |
| MACCS fingerprints | 0.763 | 0.005 | 0.819 | 0.005 | 0.791 | 0.003 | 0.789 | 0.003 | 0.860 | 0.000 | 0.588 | 0.006 | Download |
| Daylight fingerprints | 0.730 | 0.000 | 0.730 | 0.003 | 0.730 | 0.000 | 0.730 | 0.000 | 0.790 | 0.000 | 0.462 | 0.004 | Download |
| ECFP2 fingerprints | 0.904 | 0.005 | 0.920 | 0.004 | 0.912 | 0.004 | 0.911 | 0.003 | 0.960 | 0.000 | 0.830 | 0.000 | Download |
| ECFP4 fingerprints | 0.900 | 0.000 | 0.960 | 0.000 | 0.930 | 0.000 | 0.929 | 0.003 | 0.970 | 0.000 | 0.861 | 0.003 | Download |
| ECFP6 fingerprints | 0.856 | 0.005 | 0.962 | 0.000 | 0.909 | 0.003 | 0.900 | 0.000 | 0.964 | 0.005 | 0.819 | 0.003 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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