Target name

P07711: Cathepsin L1


  Protein function

Important for the overall degradation of proteins in lysosomes.

  Database links

Uniprot primary ID P07711
PDB ID 3IV2 2NQD 3H89 4AXM 1ICF 1CJL 3KSE 3OF8 3OF9 2YJC 2YJB 3HHA 3K24 3BC3 2YJ2 2YJ9 2YJ8 2XU3 2XU5 2XU4 2VHS 1CS8 4AXL 1MHW 3H8C 3H8B 3HWN 2XU1
DrugBank ID
BioGrid ID 107894
GuidetoPHARMACOLOGY ID 2351
PharmGKB ID PA162382890
KEGG ID hsa:1514
DIP ID
STRING ID 9606.ENSP00000345344
IntAct ID P07711
DMDM 115741
BRENDA 3.4.22.15
Reactome R-HSA-1474228 R-HSA-1236977 R-HSA-1442490 R-HSA-1679131 R-HSA-2132295 R-HSA-2022090
SignaLink
BioCyc
Entrez Gene (Gene ID) 1514
BindingDB P07711

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.843 0.005 0.825 0.005 0.834 0.005 0.836 0.005 0.900 0.000 0.669 0.006 Download
Estate fingerprints 0.796 0.005 0.824 0.004 0.810 0.000 0.809 0.003 0.880 0.000 0.623 0.005 Download
MACCS fingerprints 0.763 0.005 0.819 0.005 0.791 0.003 0.789 0.003 0.860 0.000 0.588 0.006 Download
Daylight fingerprints 0.730 0.000 0.730 0.003 0.730 0.000 0.730 0.000 0.790 0.000 0.462 0.004 Download
ECFP2 fingerprints 0.904 0.005 0.920 0.004 0.912 0.004 0.911 0.003 0.960 0.000 0.830 0.000 Download
ECFP4 fingerprints 0.900 0.000 0.960 0.000 0.930 0.000 0.929 0.003 0.970 0.000 0.861 0.003 Download
ECFP6 fingerprints 0.856 0.005 0.962 0.000 0.909 0.003 0.900 0.000 0.964 0.005 0.819 0.003 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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