TargetNet
  Target name

P07858: Cathepsin B

  Protein function

Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.

  Database links
Uniprot primary ID P07858
PDB ID 3CBK 3K9M 3PBH 3CBJ 1HUC 1PBH 1GMY 1CSB 2IPP 2PBH 3AI8
DrugBank ID
BioGrid ID 107888
GuidetoPHARMACOLOGY ID 2343
PharmGKB ID PA27027
KEGG ID hsa:1508
DIP ID DIP-42785N
STRING ID 9606.ENSP00000342070
IntAct ID P07858
DMDM 68067549
BRENDA 3.4.22.1
Reactome R-HSA-1679131 R-HSA-2022090 R-HSA-1442490 R-HSA-2132295
SignaLink
BioCyc
Entrez Gene (Gene ID) 1508
BindingDB P07858
  Model Performance Metrics
Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.825 0.005 0.835 0.004 0.830 0.000 0.830 0.000 0.890 0.000 0.657 0.008 Download
Estate fingerprints 0.830 0.000 0.814 0.005 0.822 0.004 0.822 0.004 0.880 0.000 0.647 0.005 Download
MACCS fingerprints 0.778 0.004 0.856 0.005 0.817 0.005 0.809 0.003 0.890 0.000 0.634 0.005 Download
Daylight fingerprints 0.801 0.003 0.779 0.004 0.790 0.000 0.790 0.000 0.820 0.000 0.576 0.005 Download
ECFP2 fingerprints 0.885 0.005 0.919 0.000 0.902 0.004 0.900 0.000 0.960 0.000 0.806 0.005 Download
ECFP4 fingerprints 0.885 0.005 0.953 0.004 0.919 0.003 0.916 0.005 0.970 0.000 0.837 0.005 Download
ECFP6 fingerprints 0.864 0.005 0.956 0.000 0.910 0.000 0.909 0.003 0.970 0.000 0.829 0.003 Download
  Download datasets
Positive dataset Negative dataset

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 E-mail: biomed@csu.edu.cn