Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.
| Uniprot primary ID | P07858 |
| PDB ID | 3CBK 3K9M 3PBH 3CBJ 1HUC 1PBH 1GMY 1CSB 2IPP 2PBH 3AI8 |
| DrugBank ID | |
| BioGrid ID | 107888 |
| GuidetoPHARMACOLOGY ID | 2343 |
| PharmGKB ID | PA27027 |
| KEGG ID | hsa:1508 |
| DIP ID | DIP-42785N |
| STRING ID | 9606.ENSP00000342070 |
| IntAct ID | P07858 |
| DMDM | 68067549 |
| BRENDA | 3.4.22.1 |
| Reactome | R-HSA-1679131 R-HSA-2022090 R-HSA-1442490 R-HSA-2132295 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 1508 |
| BindingDB | P07858 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.825 | 0.005 | 0.835 | 0.004 | 0.830 | 0.000 | 0.830 | 0.000 | 0.890 | 0.000 | 0.657 | 0.008 | Download |
| Estate fingerprints | 0.830 | 0.000 | 0.814 | 0.005 | 0.822 | 0.004 | 0.822 | 0.004 | 0.880 | 0.000 | 0.647 | 0.005 | Download |
| MACCS fingerprints | 0.778 | 0.004 | 0.856 | 0.005 | 0.817 | 0.005 | 0.809 | 0.003 | 0.890 | 0.000 | 0.634 | 0.005 | Download |
| Daylight fingerprints | 0.801 | 0.003 | 0.779 | 0.004 | 0.790 | 0.000 | 0.790 | 0.000 | 0.820 | 0.000 | 0.576 | 0.005 | Download |
| ECFP2 fingerprints | 0.885 | 0.005 | 0.919 | 0.000 | 0.902 | 0.004 | 0.900 | 0.000 | 0.960 | 0.000 | 0.806 | 0.005 | Download |
| ECFP4 fingerprints | 0.885 | 0.005 | 0.953 | 0.004 | 0.919 | 0.003 | 0.916 | 0.005 | 0.970 | 0.000 | 0.837 | 0.005 | Download |
| ECFP6 fingerprints | 0.864 | 0.005 | 0.956 | 0.000 | 0.910 | 0.000 | 0.909 | 0.003 | 0.970 | 0.000 | 0.829 | 0.003 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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