Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (By similarity). Involved in the degradation of atrial natriuretic factor (ANF) (PubMed:2966343).
| Uniprot primary ID | P07861 |
| PDB ID | |
| DrugBank ID | |
| BioGrid ID | |
| GuidetoPHARMACOLOGY ID | |
| PharmGKB ID | |
| KEGG ID | rno:24590 |
| DIP ID | |
| STRING ID | 10116.ENSRNOP00000044578 |
| IntAct ID | |
| DMDM | |
| BRENDA | 3.4.24.11 |
| Reactome | R-RNO-2022377 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 24590 |
| BindingDB | P07861 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.928 | 0.004 | 0.878 | 0.005 | 0.903 | 0.005 | 0.909 | 0.003 | 0.950 | 0.000 | 0.811 | 0.006 | Download |
| Estate fingerprints | 0.974 | 0.005 | 0.892 | 0.005 | 0.933 | 0.005 | 0.937 | 0.005 | 0.990 | 0.000 | 0.871 | 0.007 | Download |
| MACCS fingerprints | 0.964 | 0.005 | 0.900 | 0.005 | 0.932 | 0.004 | 0.937 | 0.005 | 0.980 | 0.000 | 0.870 | 0.005 | Download |
| Daylight fingerprints | 0.844 | 0.007 | 0.834 | 0.000 | 0.839 | 0.003 | 0.839 | 0.003 | 0.880 | 0.000 | 0.678 | 0.004 | Download |
| ECFP2 fingerprints | 0.998 | 0.004 | 0.930 | 0.005 | 0.964 | 0.005 | 0.964 | 0.005 | 0.990 | 0.000 | 0.933 | 0.007 | Download |
| ECFP4 fingerprints | 0.990 | 0.000 | 0.968 | 0.005 | 0.979 | 0.003 | 0.979 | 0.003 | 0.990 | 0.000 | 0.954 | 0.005 | Download |
| ECFP6 fingerprints | 0.984 | 0.005 | 0.974 | 0.000 | 0.979 | 0.003 | 0.979 | 0.003 | 1.000 | 0.000 | 0.954 | 0.005 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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