Target name

P07861: Neprilysin


  Protein function

Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (By similarity). Involved in the degradation of atrial natriuretic factor (ANF) (PubMed:2966343).

  Database links

Uniprot primary ID P07861
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID
PharmGKB ID
KEGG ID rno:24590
DIP ID
STRING ID 10116.ENSRNOP00000044578
IntAct ID
DMDM
BRENDA 3.4.24.11
Reactome R-RNO-2022377
SignaLink
BioCyc
Entrez Gene (Gene ID) 24590
BindingDB P07861

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.928 0.004 0.878 0.005 0.903 0.005 0.909 0.003 0.950 0.000 0.811 0.006 Download
Estate fingerprints 0.974 0.005 0.892 0.005 0.933 0.005 0.937 0.005 0.990 0.000 0.871 0.007 Download
MACCS fingerprints 0.964 0.005 0.900 0.005 0.932 0.004 0.937 0.005 0.980 0.000 0.870 0.005 Download
Daylight fingerprints 0.844 0.007 0.834 0.000 0.839 0.003 0.839 0.003 0.880 0.000 0.678 0.004 Download
ECFP2 fingerprints 0.998 0.004 0.930 0.005 0.964 0.005 0.964 0.005 0.990 0.000 0.933 0.007 Download
ECFP4 fingerprints 0.990 0.000 0.968 0.005 0.979 0.003 0.979 0.003 0.990 0.000 0.954 0.005 Download
ECFP6 fingerprints 0.984 0.005 0.974 0.000 0.979 0.003 0.979 0.003 1.000 0.000 0.954 0.005 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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