The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
E-mail: biomed@csu.edu.cn
 |
 |
 |
 |
 |
 |
Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes.
| Uniprot primary ID | P07900 |
| PDB ID | 1YET 2VCI 1YES 1YER 3T0H 2YK9 2YK2 3T0Z 4O0B 2CCS 2CCT 2CCU 2YJW 2CDD 2YJX 2VCJ 4L93 2XJJ 4L90 3T10 3OWB 2XJX 3OWD 2XDL 2BZ5 2XDK 4AWO 3OW6 2XDX 2XDU 2XDS 2BYI 2BYH 4EEH 4O09 4O07 2WI3 4O05 2WI1 2WI6 2WI7 2WI4 2WI5 2WI2 4FCQ 2YKE 2YKB 2YKC 3R4M 2YKJ 4CWQ |
| DrugBank ID | DB00716 DB00615 |
| BioGrid ID | 109552 |
| GuidetoPHARMACOLOGY ID | |
| PharmGKB ID | PA29519 |
| KEGG ID | hsa:3320 |
| DIP ID | DIP-27595N |
| STRING ID | 9606.ENSP00000335153 |
| IntAct ID | P07900 |
| DMDM | 92090606 |
| BRENDA | |
| Reactome | R-HSA-380270 R-HSA-4420097 R-HSA-3371511 R-HSA-12 R-HSA-2029482 R-HSA-5601884 R-HSA-2565942 R-HSA-1227986 R-HSA-399954 R-HSA-203615 R-HSA-192905 R-HSA-3371571 R-HSA-5620912 R-HSA-3371568 R-HSA-3928663 R-HSA-380259 R-HSA-5336415 R-HSA-1474151 R-HSA-3000484 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 3320 |
| BindingDB | P07900 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.696 | 0.007 | 0.990 | 0.007 | 0.843 | 0.005 | 0.815 | 0.005 | 0.900 | 0.000 | 0.713 | 0.012 | Download |
| Estate fingerprints | 0.713 | 0.008 | 0.813 | 0.008 | 0.763 | 0.005 | 0.752 | 0.004 | 0.836 | 0.005 | 0.530 | 0.008 | Download |
| MACCS fingerprints | 0.764 | 0.007 | 0.754 | 0.007 | 0.759 | 0.006 | 0.760 | 0.007 | 0.850 | 0.000 | 0.520 | 0.008 | Download |
| Daylight fingerprints | 0.677 | 0.008 | 0.801 | 0.003 | 0.739 | 0.006 | 0.720 | 0.007 | 0.774 | 0.005 | 0.481 | 0.010 | Download |
| ECFP2 fingerprints | 0.760 | 0.005 | 0.970 | 0.005 | 0.865 | 0.005 | 0.849 | 0.003 | 0.960 | 0.000 | 0.745 | 0.007 | Download |
| ECFP4 fingerprints | 0.762 | 0.010 | 0.982 | 0.005 | 0.872 | 0.006 | 0.855 | 0.007 | 0.970 | 0.000 | 0.765 | 0.010 | Download |
| ECFP6 fingerprints | 0.697 | 0.009 | 1.000 | 0.000 | 0.849 | 0.003 | 0.823 | 0.005 | 0.970 | 0.000 | 0.732 | 0.006 | Download |
| Positive dataset | Negative dataset |
The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
E-mail: biomed@csu.edu.cn
| |
|
|
| |
|
|