Target name

P07900: Heat shock protein HSP 90-alpha


  Protein function

Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes.

  Database links

Uniprot primary ID P07900
PDB ID 1YET 2VCI 1YES 1YER 3T0H 2YK9 2YK2 3T0Z 4O0B 2CCS 2CCT 2CCU 2YJW 2CDD 2YJX 2VCJ 4L93 2XJJ 4L90 3T10 3OWB 2XJX 3OWD 2XDL 2BZ5 2XDK 4AWO 3OW6 2XDX 2XDU 2XDS 2BYI 2BYH 4EEH 4O09 4O07 2WI3 4O05 2WI1 2WI6 2WI7 2WI4 2WI5 2WI2 4FCQ 2YKE 2YKB 2YKC 3R4M 2YKJ 4CWQ
DrugBank ID DB00716 DB00615
BioGrid ID 109552
GuidetoPHARMACOLOGY ID
PharmGKB ID PA29519
KEGG ID hsa:3320
DIP ID DIP-27595N
STRING ID 9606.ENSP00000335153
IntAct ID P07900
DMDM 92090606
BRENDA
Reactome R-HSA-380270 R-HSA-4420097 R-HSA-3371511 R-HSA-12 R-HSA-2029482 R-HSA-5601884 R-HSA-2565942 R-HSA-1227986 R-HSA-399954 R-HSA-203615 R-HSA-192905 R-HSA-3371571 R-HSA-5620912 R-HSA-3371568 R-HSA-3928663 R-HSA-380259 R-HSA-5336415 R-HSA-1474151 R-HSA-3000484
SignaLink
BioCyc
Entrez Gene (Gene ID) 3320
BindingDB P07900

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.696 0.007 0.990 0.007 0.843 0.005 0.815 0.005 0.900 0.000 0.713 0.012 Download
Estate fingerprints 0.713 0.008 0.813 0.008 0.763 0.005 0.752 0.004 0.836 0.005 0.530 0.008 Download
MACCS fingerprints 0.764 0.007 0.754 0.007 0.759 0.006 0.760 0.007 0.850 0.000 0.520 0.008 Download
Daylight fingerprints 0.677 0.008 0.801 0.003 0.739 0.006 0.720 0.007 0.774 0.005 0.481 0.010 Download
ECFP2 fingerprints 0.760 0.005 0.970 0.005 0.865 0.005 0.849 0.003 0.960 0.000 0.745 0.007 Download
ECFP4 fingerprints 0.762 0.010 0.982 0.005 0.872 0.006 0.855 0.007 0.970 0.000 0.765 0.010 Download
ECFP6 fingerprints 0.697 0.009 1.000 0.000 0.849 0.003 0.823 0.005 0.970 0.000 0.732 0.006 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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