Target name

P07948: Tyrosine-protein kinase Lyn


  Protein function

Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide. Mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and in mature myeloid cells, such as dendritic cells, neutrophils and eosinophils. Acts downstream of EPOR, KIT, MPL, the chemokine receptor CXCR4, as well as the receptors for IL3, IL5 and CSF2. Plays an important role in integrin signaling. Regulates cell proliferation, survival, differentiation, migration, adhesion, degranulation, and cytokine release. Down-regulates signaling pathways by phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIM), that then serve as binding sites for phosphatases, such as PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1, that modulate signaling by dephosphorylation of kinases and their substrates. Phosphorylates LIME1 in response to CD22 activation. Phosphorylates BTK, CBL, CD5, CD19, CD72, CD79A, CD79B, CSF2RB, DOK1, HCLS1, LILRB3/PIR-B, MS4A2/FCER1B, PTK2B/PYK2, SYK and TEC. Promotes phosphorylation of SIRPA, PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1. Mediates phosphorylation of the BCR-ABL fusion protein. Required for rapid phosphorylation of FER in response to FCER1 activation. Mediates KIT phosphorylation. Acts as an effector of EPOR (erythropoietin receptor) in controlling KIT expression and may play a role in erythroid differentiation during the switch between proliferation and maturation. Depending on the context, activates or inhibits several signaling cascades. Regulates phosphatidylinositol 3-kinase activity and AKT1 activation. Regulates activation of the MAP kinase signaling cascade, including activation of MAP2K1/MEK1, MAPK1/ERK2, MAPK3/ERK1, MAPK8/JNK1 and MAPK9/JNK2. Mediates activation of STAT5A and/or STAT5B. Phosphorylates LPXN on 'Tyr-72'. Kinase activity facilitates TLR4-TLR6 heterodimerization and signal initiation.

  Database links

Uniprot primary ID P07948
PDB ID 1WA7 1W1F 3A4O
DrugBank ID DB06616 DB08901 DB09079
BioGrid ID 110245
GuidetoPHARMACOLOGY ID 2060
PharmGKB ID PA30498
KEGG ID hsa:4067
DIP ID DIP-1056N
STRING ID 9606.ENSP00000428924
IntAct ID P07948
DMDM 125480
BRENDA 2.7.10.2
Reactome R-HSA-983695 R-HSA-5621480 R-HSA-1433559 R-HSA-912631 R-HSA-2029481 R-HSA-982772 R-HSA-2871809 R-HSA-3928665 R-HSA-114604 R-HSA-2871796 R-HSA-389513 R-HSA-202733 R-HSA-2454202 R-HSA-389356 R-HSA-75892 R-HSA-1433557 R-HSA-2682334 R-HSA-392866 R-HSA-2730905
SignaLink P07948
BioCyc
Entrez Gene (Gene ID) 4067
BindingDB P07948

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.791 0.003 0.901 0.004 0.846 0.005 0.838 0.004 0.924 0.005 0.696 0.005 Download
Estate fingerprints 0.796 0.008 0.744 0.006 0.770 0.007 0.777 0.007 0.870 0.000 0.542 0.013 Download
MACCS fingerprints 0.810 0.005 0.806 0.007 0.808 0.008 0.810 0.005 0.910 0.000 0.616 0.012 Download
Daylight fingerprints 0.770 0.009 0.832 0.007 0.801 0.007 0.795 0.005 0.870 0.000 0.603 0.011 Download
ECFP2 fingerprints 0.812 0.006 0.898 0.008 0.855 0.007 0.849 0.007 0.931 0.003 0.712 0.011 Download
ECFP4 fingerprints 0.769 0.010 0.949 0.000 0.859 0.006 0.844 0.007 0.940 0.000 0.730 0.008 Download
ECFP6 fingerprints 0.683 0.009 0.967 0.003 0.825 0.007 0.795 0.007 0.936 0.005 0.682 0.010 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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