The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol.
| Uniprot primary ID | P08172 |
| PDB ID | 4MQS 3UON 1LUB 4MQT |
| DrugBank ID | DB00777 DB01142 DB01062 DB00496 DB08801 DB00321 DB01148 |
| BioGrid ID | 107551 |
| GuidetoPHARMACOLOGY ID | 14 |
| PharmGKB ID | PA111 |
| KEGG ID | hsa:1129 |
| DIP ID | DIP-56282N |
| STRING ID | 9606.ENSP00000319984 |
| IntAct ID | P08172 |
| DMDM | 113122 |
| BRENDA | |
| Reactome | R-HSA-418594 R-HSA-390648 |
| SignaLink | P08172 |
| BioCyc | |
| Entrez Gene (Gene ID) | 1129 |
| BindingDB | P08172 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.889 | 0.003 | 0.811 | 0.000 | 0.850 | 0.000 | 0.851 | 0.003 | 0.920 | 0.000 | 0.698 | 0.004 | Download |
| Estate fingerprints | 0.860 | 0.000 | 0.740 | 0.004 | 0.800 | 0.000 | 0.810 | 0.000 | 0.877 | 0.005 | 0.601 | 0.006 | Download |
| MACCS fingerprints | 0.890 | 0.000 | 0.772 | 0.004 | 0.831 | 0.003 | 0.840 | 0.000 | 0.910 | 0.000 | 0.670 | 0.005 | Download |
| Daylight fingerprints | 0.834 | 0.005 | 0.744 | 0.003 | 0.789 | 0.003 | 0.798 | 0.004 | 0.820 | 0.000 | 0.575 | 0.005 | Download |
| ECFP2 fingerprints | 0.900 | 0.000 | 0.896 | 0.000 | 0.898 | 0.004 | 0.899 | 0.003 | 0.960 | 0.000 | 0.795 | 0.005 | Download |
| ECFP4 fingerprints | 0.888 | 0.004 | 0.932 | 0.005 | 0.910 | 0.000 | 0.910 | 0.000 | 0.960 | 0.000 | 0.823 | 0.005 | Download |
| ECFP6 fingerprints | 0.855 | 0.005 | 0.959 | 0.005 | 0.907 | 0.005 | 0.900 | 0.000 | 0.960 | 0.000 | 0.815 | 0.005 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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