Target name

P08172: Muscarinic acetylcholine receptor M2


  Protein function

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol.

  Database links

Uniprot primary ID P08172
PDB ID 4MQS 3UON 1LUB 4MQT
DrugBank ID DB00777 DB01142 DB01062 DB00496 DB08801 DB00321 DB01148
BioGrid ID 107551
GuidetoPHARMACOLOGY ID 14
PharmGKB ID PA111
KEGG ID hsa:1129
DIP ID DIP-56282N
STRING ID 9606.ENSP00000319984
IntAct ID P08172
DMDM 113122
BRENDA
Reactome R-HSA-418594 R-HSA-390648
SignaLink P08172
BioCyc
Entrez Gene (Gene ID) 1129
BindingDB P08172

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.889 0.003 0.811 0.000 0.850 0.000 0.851 0.003 0.920 0.000 0.698 0.004 Download
Estate fingerprints 0.860 0.000 0.740 0.004 0.800 0.000 0.810 0.000 0.877 0.005 0.601 0.006 Download
MACCS fingerprints 0.890 0.000 0.772 0.004 0.831 0.003 0.840 0.000 0.910 0.000 0.670 0.005 Download
Daylight fingerprints 0.834 0.005 0.744 0.003 0.789 0.003 0.798 0.004 0.820 0.000 0.575 0.005 Download
ECFP2 fingerprints 0.900 0.000 0.896 0.000 0.898 0.004 0.899 0.003 0.960 0.000 0.795 0.005 Download
ECFP4 fingerprints 0.888 0.004 0.932 0.005 0.910 0.000 0.910 0.000 0.960 0.000 0.823 0.005 Download
ECFP6 fingerprints 0.855 0.005 0.959 0.005 0.907 0.005 0.900 0.000 0.960 0.000 0.815 0.005 Download

  Download datasets

Positive dataset Negative dataset


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 E-mail: biomed@csu.edu.cn