The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase.
| Uniprot primary ID | P08173 |
| PDB ID | |
| DrugBank ID | DB00777 DB01142 DB00496 DB01625 DB00321 DB01224 DB00420 |
| BioGrid ID | 107554 |
| GuidetoPHARMACOLOGY ID | 16 |
| PharmGKB ID | PA26485 |
| KEGG ID | hsa:1132 |
| DIP ID | DIP-61455N |
| STRING ID | 9606.ENSP00000409378 |
| IntAct ID | |
| DMDM | 23503039 |
| BRENDA | |
| Reactome | R-HSA-418594 R-HSA-390648 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 1132 |
| BindingDB | P08173 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.827 | 0.005 | 0.829 | 0.004 | 0.828 | 0.004 | 0.828 | 0.004 | 0.900 | 0.000 | 0.659 | 0.009 | Download |
| Estate fingerprints | 0.715 | 0.008 | 0.745 | 0.010 | 0.730 | 0.007 | 0.727 | 0.007 | 0.800 | 0.000 | 0.461 | 0.010 | Download |
| MACCS fingerprints | 0.721 | 0.006 | 0.743 | 0.007 | 0.732 | 0.004 | 0.730 | 0.000 | 0.829 | 0.003 | 0.462 | 0.004 | Download |
| Daylight fingerprints | 0.656 | 0.008 | 0.754 | 0.005 | 0.705 | 0.005 | 0.692 | 0.004 | 0.767 | 0.005 | 0.417 | 0.008 | Download |
| ECFP2 fingerprints | 0.876 | 0.005 | 0.846 | 0.008 | 0.861 | 0.006 | 0.863 | 0.005 | 0.940 | 0.000 | 0.723 | 0.009 | Download |
| ECFP4 fingerprints | 0.882 | 0.004 | 0.892 | 0.005 | 0.887 | 0.005 | 0.887 | 0.005 | 0.946 | 0.005 | 0.776 | 0.007 | Download |
| ECFP6 fingerprints | 0.864 | 0.008 | 0.900 | 0.005 | 0.882 | 0.004 | 0.882 | 0.004 | 0.940 | 0.000 | 0.771 | 0.009 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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