Target name

P08183: Multidrug resistance protein 1


  Protein function

Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.

  Database links

Uniprot primary ID P08183
PDB ID
DrugBank ID DB00950 DB00773 DB04573 DB01169 DB00959 DB00675 DB00936
BioGrid ID 111262
GuidetoPHARMACOLOGY ID
PharmGKB ID PA267
KEGG ID hsa:5243
DIP ID
STRING ID 9606.ENSP00000265724
IntAct ID P08183
DMDM 238054374
BRENDA 3.6.3.44
Reactome R-HSA-382556 R-HSA-2161517
SignaLink
BioCyc
Entrez Gene (Gene ID) 5243
BindingDB P08183

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.786 0.005 0.844 0.006 0.815 0.005 0.807 0.005 0.889 0.003 0.629 0.007 Download
Estate fingerprints 0.795 0.005 0.751 0.003 0.773 0.005 0.777 0.005 0.847 0.005 0.547 0.008 Download
MACCS fingerprints 0.809 0.006 0.797 0.005 0.803 0.005 0.802 0.004 0.877 0.005 0.604 0.010 Download
Daylight fingerprints 0.729 0.003 0.773 0.003 0.751 0.003 0.742 0.004 0.812 0.004 0.505 0.007 Download
ECFP2 fingerprints 0.882 0.004 0.870 0.005 0.876 0.005 0.872 0.004 0.942 0.004 0.751 0.003 Download
ECFP4 fingerprints 0.877 0.005 0.943 0.005 0.910 0.000 0.904 0.005 0.950 0.000 0.819 0.003 Download
ECFP6 fingerprints 0.845 0.005 0.971 0.005 0.908 0.004 0.900 0.000 0.950 0.000 0.818 0.004 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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 E-mail: biomed@csu.edu.cn