Target name

P08235: Mineralocorticoid receptor


  Protein function

Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels.

  Database links

Uniprot primary ID P08235
PDB ID 2OAX 1Y9R 3WFF 3WFG 1YA3 2A3I 2AAX 4PF3 4TNT 2AB2 2AA6 2ABI 2AA2 2AA5 3VHV 3VHU 2AA7
DrugBank ID DB00588 DB01395 DB00687 DB01023 DB00700 DB00393 DB00396
BioGrid ID 110451
GuidetoPHARMACOLOGY ID 626
PharmGKB ID PA242
KEGG ID hsa:4306
DIP ID
STRING ID 9606.ENSP00000341390
IntAct ID P08235
DMDM 126885
BRENDA
Reactome R-HSA-383280
SignaLink P08235
BioCyc
Entrez Gene (Gene ID) 4306
BindingDB P08235

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.849 0.009 0.951 0.000 0.900 0.000 0.895 0.005 0.970 0.000 0.805 0.005 Download
Estate fingerprints 0.859 0.003 0.827 0.000 0.843 0.005 0.846 0.005 0.920 0.000 0.689 0.006 Download
MACCS fingerprints 0.852 0.004 0.870 0.000 0.861 0.003 0.860 0.000 0.930 0.000 0.719 0.006 Download
Daylight fingerprints 0.854 0.005 0.882 0.003 0.868 0.004 0.862 0.004 0.900 0.000 0.731 0.006 Download
ECFP2 fingerprints 0.940 0.000 0.942 0.004 0.941 0.003 0.941 0.003 0.990 0.000 0.884 0.005 Download
ECFP4 fingerprints 0.937 0.005 0.977 0.000 0.957 0.005 0.955 0.005 0.990 0.000 0.912 0.004 Download
ECFP6 fingerprints 0.899 0.006 0.983 0.005 0.941 0.003 0.940 0.000 0.990 0.000 0.888 0.004 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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