The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
E-mail: biomed@csu.edu.cn
 |
 |
 |
 |
 |
 |
Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels.
| Uniprot primary ID | P08235 |
| PDB ID | 2OAX 1Y9R 3WFF 3WFG 1YA3 2A3I 2AAX 4PF3 4TNT 2AB2 2AA6 2ABI 2AA2 2AA5 3VHV 3VHU 2AA7 |
| DrugBank ID | DB00588 DB01395 DB00687 DB01023 DB00700 DB00393 DB00396 |
| BioGrid ID | 110451 |
| GuidetoPHARMACOLOGY ID | 626 |
| PharmGKB ID | PA242 |
| KEGG ID | hsa:4306 |
| DIP ID | |
| STRING ID | 9606.ENSP00000341390 |
| IntAct ID | P08235 |
| DMDM | 126885 |
| BRENDA | |
| Reactome | R-HSA-383280 |
| SignaLink | P08235 |
| BioCyc | |
| Entrez Gene (Gene ID) | 4306 |
| BindingDB | P08235 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.849 | 0.009 | 0.951 | 0.000 | 0.900 | 0.000 | 0.895 | 0.005 | 0.970 | 0.000 | 0.805 | 0.005 | Download |
| Estate fingerprints | 0.859 | 0.003 | 0.827 | 0.000 | 0.843 | 0.005 | 0.846 | 0.005 | 0.920 | 0.000 | 0.689 | 0.006 | Download |
| MACCS fingerprints | 0.852 | 0.004 | 0.870 | 0.000 | 0.861 | 0.003 | 0.860 | 0.000 | 0.930 | 0.000 | 0.719 | 0.006 | Download |
| Daylight fingerprints | 0.854 | 0.005 | 0.882 | 0.003 | 0.868 | 0.004 | 0.862 | 0.004 | 0.900 | 0.000 | 0.731 | 0.006 | Download |
| ECFP2 fingerprints | 0.940 | 0.000 | 0.942 | 0.004 | 0.941 | 0.003 | 0.941 | 0.003 | 0.990 | 0.000 | 0.884 | 0.005 | Download |
| ECFP4 fingerprints | 0.937 | 0.005 | 0.977 | 0.000 | 0.957 | 0.005 | 0.955 | 0.005 | 0.990 | 0.000 | 0.912 | 0.004 | Download |
| ECFP6 fingerprints | 0.899 | 0.006 | 0.983 | 0.005 | 0.941 | 0.003 | 0.940 | 0.000 | 0.990 | 0.000 | 0.888 | 0.004 | Download |
| Positive dataset | Negative dataset |
The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
E-mail: biomed@csu.edu.cn
| |
|
|
| |
|
|