Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.
| Uniprot primary ID | P08238 |
| PDB ID | 1QZ2 2L6J 3PRY 1UYM 3FWV 3NMQ 3UQ3 |
| DrugBank ID | |
| BioGrid ID | 109558 |
| GuidetoPHARMACOLOGY ID | |
| PharmGKB ID | PA29524 |
| KEGG ID | hsa:3326 |
| DIP ID | DIP-413N |
| STRING ID | 9606.ENSP00000325875 |
| IntAct ID | P08238 |
| DMDM | 17865718 |
| BRENDA | |
| Reactome | R-HSA-3371511 R-HSA-844456 R-HSA-2029482 R-HSA-399954 R-HSA-3371571 R-HSA-3371568 R-HSA-5336415 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 3326 |
| BindingDB | P08238 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.824 | 0.005 | 0.976 | 0.003 | 0.900 | 0.000 | 0.890 | 0.000 | 0.962 | 0.004 | 0.804 | 0.005 | Download |
| Estate fingerprints | 0.842 | 0.008 | 0.796 | 0.005 | 0.819 | 0.003 | 0.823 | 0.005 | 0.900 | 0.000 | 0.638 | 0.008 | Download |
| MACCS fingerprints | 0.803 | 0.011 | 0.823 | 0.003 | 0.813 | 0.005 | 0.812 | 0.006 | 0.910 | 0.000 | 0.627 | 0.011 | Download |
| Daylight fingerprints | 0.893 | 0.005 | 0.807 | 0.004 | 0.850 | 0.000 | 0.854 | 0.005 | 0.881 | 0.003 | 0.700 | 0.005 | Download |
| ECFP2 fingerprints | 0.927 | 0.005 | 0.957 | 0.003 | 0.942 | 0.004 | 0.940 | 0.000 | 0.982 | 0.004 | 0.888 | 0.004 | Download |
| ECFP4 fingerprints | 0.919 | 0.003 | 0.987 | 0.000 | 0.953 | 0.005 | 0.950 | 0.000 | 0.990 | 0.000 | 0.910 | 0.000 | Download |
| ECFP6 fingerprints | 0.895 | 0.005 | 0.997 | 0.000 | 0.946 | 0.005 | 0.941 | 0.003 | 0.990 | 0.000 | 0.896 | 0.005 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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