Target name

P08238: Heat shock protein HSP 90-beta


  Protein function

Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.

  Database links

Uniprot primary ID P08238
PDB ID 1QZ2 2L6J 3PRY 1UYM 3FWV 3NMQ 3UQ3
DrugBank ID
BioGrid ID 109558
GuidetoPHARMACOLOGY ID
PharmGKB ID PA29524
KEGG ID hsa:3326
DIP ID DIP-413N
STRING ID 9606.ENSP00000325875
IntAct ID P08238
DMDM 17865718
BRENDA
Reactome R-HSA-3371511 R-HSA-844456 R-HSA-2029482 R-HSA-399954 R-HSA-3371571 R-HSA-3371568 R-HSA-5336415
SignaLink
BioCyc
Entrez Gene (Gene ID) 3326
BindingDB P08238

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.824 0.005 0.976 0.003 0.900 0.000 0.890 0.000 0.962 0.004 0.804 0.005 Download
Estate fingerprints 0.842 0.008 0.796 0.005 0.819 0.003 0.823 0.005 0.900 0.000 0.638 0.008 Download
MACCS fingerprints 0.803 0.011 0.823 0.003 0.813 0.005 0.812 0.006 0.910 0.000 0.627 0.011 Download
Daylight fingerprints 0.893 0.005 0.807 0.004 0.850 0.000 0.854 0.005 0.881 0.003 0.700 0.005 Download
ECFP2 fingerprints 0.927 0.005 0.957 0.003 0.942 0.004 0.940 0.000 0.982 0.004 0.888 0.004 Download
ECFP4 fingerprints 0.919 0.003 0.987 0.000 0.953 0.005 0.950 0.000 0.990 0.000 0.910 0.000 Download
ECFP6 fingerprints 0.895 0.005 0.997 0.000 0.946 0.005 0.941 0.003 0.990 0.000 0.896 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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