Modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis.
| Uniprot primary ID | P08246 |
| PDB ID | 5A09 1H1B 1PPG 1PPF 1B0F 4NZL 2Z7F 4WVP 5A0A 2RG3 5A0B 5A0C 5ABW 1HNE 3Q77 3Q76 |
| DrugBank ID | DB00019 DB00058 DB00099 |
| BioGrid ID | 108306 |
| GuidetoPHARMACOLOGY ID | 2358 |
| PharmGKB ID | PA27735 |
| KEGG ID | hsa:1991 |
| DIP ID | |
| STRING ID | 9606.ENSP00000263621 |
| IntAct ID | P08246 |
| DMDM | 119292 |
| BRENDA | 3.4.21.37 |
| Reactome | R-HSA-1592389 R-HSA-1474228 R-HSA-1442490 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 1991 |
| BindingDB | P08246 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.827 | 0.005 | 0.953 | 0.003 | 0.890 | 0.000 | 0.885 | 0.005 | 0.950 | 0.000 | 0.791 | 0.003 | Download |
| Estate fingerprints | 0.800 | 0.000 | 0.720 | 0.005 | 0.760 | 0.000 | 0.770 | 0.000 | 0.850 | 0.000 | 0.517 | 0.005 | Download |
| MACCS fingerprints | 0.815 | 0.005 | 0.845 | 0.005 | 0.830 | 0.000 | 0.830 | 0.000 | 0.910 | 0.000 | 0.661 | 0.003 | Download |
| Daylight fingerprints | 0.790 | 0.000 | 0.810 | 0.000 | 0.800 | 0.000 | 0.800 | 0.000 | 0.820 | 0.000 | 0.602 | 0.004 | Download |
| ECFP2 fingerprints | 0.857 | 0.005 | 0.979 | 0.000 | 0.918 | 0.004 | 0.910 | 0.000 | 0.980 | 0.000 | 0.839 | 0.003 | Download |
| ECFP4 fingerprints | 0.839 | 0.003 | 0.983 | 0.000 | 0.911 | 0.003 | 0.908 | 0.004 | 0.984 | 0.005 | 0.838 | 0.004 | Download |
| ECFP6 fingerprints | 0.802 | 0.004 | 0.994 | 0.000 | 0.898 | 0.004 | 0.888 | 0.004 | 0.980 | 0.000 | 0.808 | 0.004 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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