TargetNet
  Target name

P08246: Neutrophil elastase

  Protein function

Modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis.

  Database links
Uniprot primary ID P08246
PDB ID 5A09 1H1B 1PPG 1PPF 1B0F 4NZL 2Z7F 4WVP 5A0A 2RG3 5A0B 5A0C 5ABW 1HNE 3Q77 3Q76
DrugBank ID DB00019 DB00058 DB00099
BioGrid ID 108306
GuidetoPHARMACOLOGY ID 2358
PharmGKB ID PA27735
KEGG ID hsa:1991
DIP ID
STRING ID 9606.ENSP00000263621
IntAct ID P08246
DMDM 119292
BRENDA 3.4.21.37
Reactome R-HSA-1592389 R-HSA-1474228 R-HSA-1442490
SignaLink
BioCyc
Entrez Gene (Gene ID) 1991
BindingDB P08246
  Model Performance Metrics
Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.827 0.005 0.953 0.003 0.890 0.000 0.885 0.005 0.950 0.000 0.791 0.003 Download
Estate fingerprints 0.800 0.000 0.720 0.005 0.760 0.000 0.770 0.000 0.850 0.000 0.517 0.005 Download
MACCS fingerprints 0.815 0.005 0.845 0.005 0.830 0.000 0.830 0.000 0.910 0.000 0.661 0.003 Download
Daylight fingerprints 0.790 0.000 0.810 0.000 0.800 0.000 0.800 0.000 0.820 0.000 0.602 0.004 Download
ECFP2 fingerprints 0.857 0.005 0.979 0.000 0.918 0.004 0.910 0.000 0.980 0.000 0.839 0.003 Download
ECFP4 fingerprints 0.839 0.003 0.983 0.000 0.911 0.003 0.908 0.004 0.984 0.005 0.838 0.004 Download
ECFP6 fingerprints 0.802 0.004 0.994 0.000 0.898 0.004 0.888 0.004 0.980 0.000 0.808 0.004 Download
  Download datasets
Positive dataset Negative dataset

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 E-mail: biomed@csu.edu.cn