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E-mail: biomed@csu.edu.cn
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Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase.
| Uniprot primary ID | P08254 |
| PDB ID | 1B3D 1UEA 1C3I 2SRT 1BM6 1UMS 1UMT 1BQO 1HFS 1G05 1G49 1OO9 1SLM 1SLN 1CQR 1USN 4JA1 1D8M 1D8F 2USN 1CAQ 1C8T 4DPE 1D7X 1M1W 3OHO 3OHL 1G4K 2JNP 1D5J 1QIA 1QIC 1HY7 3USN 4G9L 2JT5 2JT6 1CIZ 2D1O 1B8Y 1BIW |
| DrugBank ID | DB00786 |
| BioGrid ID | 110458 |
| GuidetoPHARMACOLOGY ID | 1630 |
| PharmGKB ID | PA30886 |
| KEGG ID | hsa:4314 |
| DIP ID | |
| STRING ID | 9606.ENSP00000299855 |
| IntAct ID | P08254 |
| DMDM | 116857 |
| BRENDA | |
| Reactome | R-HSA-1592389 R-HSA-2179392 R-HSA-2022090 R-HSA-1474228 R-HSA-1442490 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 4314 |
| BindingDB | P08254 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.888 | 0.004 | 0.880 | 0.000 | 0.884 | 0.005 | 0.884 | 0.005 | 0.947 | 0.005 | 0.770 | 0.000 | Download |
| Estate fingerprints | 0.880 | 0.000 | 0.820 | 0.003 | 0.850 | 0.000 | 0.850 | 0.000 | 0.930 | 0.000 | 0.698 | 0.004 | Download |
| MACCS fingerprints | 0.865 | 0.005 | 0.875 | 0.000 | 0.870 | 0.000 | 0.870 | 0.000 | 0.950 | 0.000 | 0.734 | 0.005 | Download |
| Daylight fingerprints | 0.800 | 0.000 | 0.880 | 0.005 | 0.840 | 0.000 | 0.835 | 0.005 | 0.910 | 0.000 | 0.685 | 0.005 | Download |
| ECFP2 fingerprints | 0.930 | 0.000 | 0.930 | 0.000 | 0.930 | 0.000 | 0.930 | 0.000 | 0.980 | 0.000 | 0.852 | 0.004 | Download |
| ECFP4 fingerprints | 0.947 | 0.005 | 0.953 | 0.000 | 0.950 | 0.000 | 0.950 | 0.000 | 0.990 | 0.000 | 0.899 | 0.003 | Download |
| ECFP6 fingerprints | 0.930 | 0.000 | 0.968 | 0.003 | 0.949 | 0.003 | 0.945 | 0.005 | 0.990 | 0.000 | 0.892 | 0.004 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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