Target name

P08254: Stromelysin-1


  Protein function

Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase.

  Database links

Uniprot primary ID P08254
PDB ID 1B3D 1UEA 1C3I 2SRT 1BM6 1UMS 1UMT 1BQO 1HFS 1G05 1G49 1OO9 1SLM 1SLN 1CQR 1USN 4JA1 1D8M 1D8F 2USN 1CAQ 1C8T 4DPE 1D7X 1M1W 3OHO 3OHL 1G4K 2JNP 1D5J 1QIA 1QIC 1HY7 3USN 4G9L 2JT5 2JT6 1CIZ 2D1O 1B8Y 1BIW
DrugBank ID DB00786
BioGrid ID 110458
GuidetoPHARMACOLOGY ID 1630
PharmGKB ID PA30886
KEGG ID hsa:4314
DIP ID
STRING ID 9606.ENSP00000299855
IntAct ID P08254
DMDM 116857
BRENDA
Reactome R-HSA-1592389 R-HSA-2179392 R-HSA-2022090 R-HSA-1474228 R-HSA-1442490
SignaLink
BioCyc
Entrez Gene (Gene ID) 4314
BindingDB P08254

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.888 0.004 0.880 0.000 0.884 0.005 0.884 0.005 0.947 0.005 0.770 0.000 Download
Estate fingerprints 0.880 0.000 0.820 0.003 0.850 0.000 0.850 0.000 0.930 0.000 0.698 0.004 Download
MACCS fingerprints 0.865 0.005 0.875 0.000 0.870 0.000 0.870 0.000 0.950 0.000 0.734 0.005 Download
Daylight fingerprints 0.800 0.000 0.880 0.005 0.840 0.000 0.835 0.005 0.910 0.000 0.685 0.005 Download
ECFP2 fingerprints 0.930 0.000 0.930 0.000 0.930 0.000 0.930 0.000 0.980 0.000 0.852 0.004 Download
ECFP4 fingerprints 0.947 0.005 0.953 0.000 0.950 0.000 0.950 0.000 0.990 0.000 0.899 0.003 Download
ECFP6 fingerprints 0.930 0.000 0.968 0.003 0.949 0.003 0.945 0.005 0.990 0.000 0.892 0.004 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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