Target name

P08311: Cathepsin G


  Protein function

Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe-CH2Cl and phenylmethylsulfonyl fluoride.

  Database links

Uniprot primary ID P08311
PDB ID 1CGH 1T32 1AU8 1KYN
DrugBank ID
BioGrid ID 107891
GuidetoPHARMACOLOGY ID 2348
PharmGKB ID PA27032
KEGG ID hsa:1511
DIP ID
STRING ID 9606.ENSP00000216336
IntAct ID P08311
DMDM 115725
BRENDA 3.4.21.20
Reactome R-HSA-1592389 R-HSA-381426 R-HSA-2022377 R-HSA-1474228
SignaLink
BioCyc
Entrez Gene (Gene ID) 1511
BindingDB P08311

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.777 0.014 0.869 0.011 0.823 0.011 0.814 0.011 0.914 0.005 0.650 0.019 Download
Estate fingerprints 0.821 0.019 0.583 0.011 0.702 0.010 0.735 0.011 0.789 0.006 0.415 0.023 Download
MACCS fingerprints 0.774 0.015 0.780 0.009 0.777 0.008 0.777 0.008 0.858 0.004 0.556 0.018 Download
Daylight fingerprints 0.597 0.015 0.947 0.005 0.772 0.008 0.721 0.011 0.866 0.012 0.576 0.014 Download
ECFP2 fingerprints 0.942 0.006 0.872 0.004 0.907 0.005 0.908 0.004 0.963 0.005 0.814 0.010 Download
ECFP4 fingerprints 0.899 0.010 0.887 0.012 0.893 0.005 0.894 0.005 0.960 0.000 0.788 0.014 Download
ECFP6 fingerprints 0.876 0.007 0.934 0.008 0.905 0.007 0.902 0.006 0.968 0.004 0.810 0.012 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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