Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids (PubMed:15283675, PubMed:8168535). Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (PubMed:17101991). Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (PubMed:15283675). Involved in the degradation of atrial natriuretic factor (ANF) (PubMed:2531377, PubMed:2972276). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (PubMed:20876573).
| Uniprot primary ID | P08473 |
| PDB ID | 2QPJ 1DL9 1DMT 1QVD 2YB9 4CTH 1R1J 1R1H 1R1I 1Y8J |
| DrugBank ID | DB00616 DB06655 |
| BioGrid ID | 110455 |
| GuidetoPHARMACOLOGY ID | 1611 |
| PharmGKB ID | PA30864 |
| KEGG ID | hsa:4311 |
| DIP ID | |
| STRING ID | 9606.ENSP00000353679 |
| IntAct ID | P08473 |
| DMDM | 128062 |
| BRENDA | 3.4.24.11 |
| Reactome | R-HSA-2022377 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 4311 |
| BindingDB | P08473 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.906 | 0.005 | 0.928 | 0.005 | 0.917 | 0.005 | 0.915 | 0.005 | 0.970 | 0.000 | 0.832 | 0.006 | Download |
| Estate fingerprints | 0.974 | 0.005 | 0.936 | 0.003 | 0.955 | 0.005 | 0.959 | 0.003 | 0.990 | 0.000 | 0.911 | 0.003 | Download |
| MACCS fingerprints | 0.952 | 0.004 | 0.936 | 0.000 | 0.944 | 0.005 | 0.947 | 0.005 | 0.980 | 0.000 | 0.889 | 0.003 | Download |
| Daylight fingerprints | 0.822 | 0.004 | 0.798 | 0.000 | 0.810 | 0.000 | 0.811 | 0.003 | 0.868 | 0.004 | 0.620 | 0.005 | Download |
| ECFP2 fingerprints | 0.981 | 0.003 | 0.959 | 0.004 | 0.970 | 0.000 | 0.970 | 0.000 | 1.000 | 0.000 | 0.941 | 0.003 | Download |
| ECFP4 fingerprints | 0.980 | 0.000 | 0.964 | 0.005 | 0.972 | 0.004 | 0.972 | 0.004 | 1.000 | 0.000 | 0.950 | 0.000 | Download |
| ECFP6 fingerprints | 0.970 | 0.000 | 0.988 | 0.003 | 0.979 | 0.003 | 0.979 | 0.003 | 1.000 | 0.000 | 0.951 | 0.003 | Download |
| Positive dataset | Negative dataset |
The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
E-mail: jiedong@csu.edu.cn
 |
 |
 |
 |
 |
 |